Abstract

The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system which is considered to be stable, robust quality and enhanced dissolution rate. To optimize the method of manufacture by formulate the Ciprofloxacin solid dispersion system by various techniques like Physical mixing, Co-grinding, Kneading and solvent evaporation techniques. The disintegrating agent used in the present study is Croscarmellose sodium.. To study the dissolution of Ciprofloxacin solid dispersion system by using the Physical mixing, Co-grinding, Kneading and solvent evaporation techniques, Optimization of formula. Among the four different techniques used for preparation o solid dispersions solvent evaporation technique has shown the increase in dissolution rate that is the Trail-5 was found to have a faster solubility and dissolution property which was prepared by using Croscarmellose sodium as a disintegrant in the ratio of 1:1.

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