Design and Evaluation of Imatinib Mesylate Loaded Microspheres for Stomach Specific Drug Delivery
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 3
Abstract
Aims: The aim of the present work was to design and evaluate the Imatinib mesylate microspheres using natural and semi synthetic polymers for stomach specific drug delivery. Study Design: Design and Evaluation of Imatinib Mesylate loaded microspheres Place and Duration of the Study: The study was carried out in Department of Pharmaceutics, JKKMMRF’s Annai JKK Sampoorani Ammal College of Pharmacy, between November 2012 and July 2013. Methodology: The microspheres were prepared using Sodium alginate as a polymer by Emulsification Ionic Gelation Technique. Copolymers of natural origin namely Guar gum, Karaya gum, Chitosan and semi synthetic origin namely Hydroxy propoylmethyl cellulose K4M, K15M, K100M are used as mucoadhesive polymers. The prepared microspheres were evaluated for their percentage yield, entrapment efficiency, degree of swelling, particle size, surface morphology and in-vitro mucoadhesion, drug release studies. Drug release kinetics was determined from drug release data. Selected formulations are subjected to stability studies under varying conditions of temperature and humidity. Results: The production yields of microspheres were found to be between 76.74 to 88.18%. Percentage drug entrapment efficiency of Imatinib mesylate microspheres was ranged from 65.51 to 88.78%. Particle size of the prepared microspheres was in the size range of 440-810µm. SEM analysis revealed that all the prepared microspheres were discrete, spherical in shape. The in-vitro mucoadhesive study demonstrated that Hydroxy propoylmethyl cellulose adhered to the mucus to a greater extent than other polymers. The in-vitro release study shows that, retarded release with increase in percentage of polymers. The release of drug from the microspheres followed Krosmeyer Peppas kinetics. After the stability studies, the formulations remained stable at the end of storage period. Conclusion: Based on the results, it was concluded that, the formulations with natural polymers were found to be best than semi synthetic polymers for the oral delivery of Imatinib mesylate.
Authors and Affiliations
Rangasamy Manivannan, Bandaru Lakshmi Narayana Rao, Venkata Krishna Reddy
Keywords
Related Articles
- EP ID EP344636
- DOI 10.9734/BJPR/2014/6444
- Views 104
- Downloads 0
Erythropoietic Effects of Eremomastax polysperma Leaf Extracts on Female Prepubertal and Pubertal Wistar Rats
This study assessed the erythropoietic effect of Eremomastax polysperma leaf extracts in female albino Wistar rats. Method: Twenty eight (28) female rats were divided into two major groups based on their weight and age....
Preparation of Poly(3-hydroxybutyrate) Micro- and Nanoparticles as Hydrophobic Drugs Carrier Using Self-emulsifying Nanoemulsion Method
Aims: To correlate the different sizes and morphologies of polymeric particles prepared through the oil-in-water micro- and nanoemulsions. Study Design: Poly(3-hydroxybutyrate) (PHB) micro- and nanoparticles were prepare...
In vitro Synergistic Action of Honey and Essential Oils against Two Species of Aspergillus: A Preliminary Study
In order to evaluate the synergistic action of essential oils (EO) on the antifungal activity of honey, a comparative method of adding honey with and without EO to culture media was used. One variety of honey and five EO...
Comparison of the Effects of Ropivacaine and Bupivacaine on Human Umblical Artery Vasoreactivity
The primary aim of the current study was to examine the effect of ropivacaine and bupivacaine on human umblical artery reactivity and on clinical outcomes. Neither bupivacaine nor ropivacaine produce a significant effect...
Ameliorative Effects of Alcohol on Human Diabetic Volunteers – A Prospective Study
Aims: The purpose of this study is to assess and confirm the ameliorative effects of alcohol consumption on biochemical indices of blood i.e., blood glucose, HbA1c, NO2, NO3, lipid profiles, hs-CRP (high sensitive C–Reac...