Design and Evaluation of Sustained release Floating tablets for the treatment of Gastric Ulcers
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
The present study was carried out with an objective of preparation of ranitidine hydrochloride sustained release formulation for 24 hrs. Various formulations were prepared by wet granulation technique using the polymers, such as HPMC K100M and HPMC K15M. It was found that the best formulation for RT8 was having the floating lag time of 120 sec and showed 98.4% drug release at the end of 24 hours. This way the best formulation was achieved by using the combination of high and low viscous polymers HPMC K100M and HPMC K15M in the ratio of 1:1.In-vitro drug release studies of Ranitidine hydrochloride sustained release floating tablets showed that, the rate of drug release is diffusion controlled and follows zero order kinetics.
Authors and Affiliations
Rajesh Kaza , E. Usharani , R. Nagaraju , R. Haribabu , P. V. Siva Reddy
Keywords
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