Design and In Vitro Evaluation of Buccal Film of Terfenadine
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 7
Abstract
The buccal films of Terfenadine were formulated using mucoadhesive polymers like Sodium alginate, Sodium carboxy methyl cellulose, Hydroxy propyl methyl cellulose. The films were evaluated for their folding endurance, drug content uniformity, moisture content, weight variation, surface pH, an in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. The films were found to have good tensile strength and elasticity. The drug content was found to be uniform. The buccal films prepared with Sodium alginate are having good drug release. All of these buccal patches slowly released the drug incorporated and sustained over a period of 180 minutes. The drug release from buccal films varied with respect to the polymer composition. Among all formulations, the maximum in vitro drug release was observed in the case of formulation F1(85%).
Authors and Affiliations
M. Komala , P. Shanmugapandiyan , N. Shalini , K. Hima Bindu , K. P. Sampath kumar , Debjit Bhowmik
Keywords
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