Design and In Vitro Evaluation of Buccal Film of Terfenadine
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 7
Abstract
The buccal films of Terfenadine were formulated using mucoadhesive polymers like Sodium alginate, Sodium carboxy methyl cellulose, Hydroxy propyl methyl cellulose. The films were evaluated for their folding endurance, drug content uniformity, moisture content, weight variation, surface pH, an in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. The films were found to have good tensile strength and elasticity. The drug content was found to be uniform. The buccal films prepared with Sodium alginate are having good drug release. All of these buccal patches slowly released the drug incorporated and sustained over a period of 180 minutes. The drug release from buccal films varied with respect to the polymer composition. Among all formulations, the maximum in vitro drug release was observed in the case of formulation F1(85%).
Authors and Affiliations
M. Komala , P. Shanmugapandiyan , N. Shalini , K. Hima Bindu , K. P. Sampath kumar , Debjit Bhowmik
Keywords
Related Articles
- EP ID EP145782
- DOI -
- Views 86
- Downloads 0
Diabetes Epidemic in India-- A Comprehensive Review of Clinical Features, Management and Remedies
India, the world’s second most populous country, now has more people with type 2 diabetes (more than 50 million) than any other nation. With India having the highest number of diabetic patients in the world, the sugar di...
Osmotic-Controlled Release Oral Delivery System: An Advanced Oral Delivery Form
The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually once-daily, in several therapeutic ar...
Physico-Chemical Standardization of Tankana (Borax): An Ayurvedic Mineral Drug
Tankana, which is one among the Ksharatrayas has been used since very long time in Ayurveda. It has a wide range of therapeutic applications, including diseases like Vrana (ulcers), Shvasa (asthma), Kasa (cough), etc. Th...
Comparison of Emulsification and Ionic Gelation Method of Preparation of Mucoadhesive Microsphere
The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic...
Resealed Erythrocytes as a Carrier for Drug Targeting: A Review
Erythrocytes have been the most interesting carrier and have found to possess great potential in drug targeting. Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body...