Design and In-vitro Evaluation of Silymarin Bilayer Tablets
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 6
Abstract
In the present study an attempt was made to study the effect of formulation variables on bilayered floating tablet of Silymarin. Immediate release layer was formulated by using various super disintegrants such as sodium starch glycolate, cross carmellose sodium, crospovidone and sustained release layer was formulated with different grades of hydrophilic polymers like HPMCK4M, HPMCK5M and HPMCK100M by wet granulation method. The influence of polymer and their concentrations were also investigated. The prepared tablets were characterized and rate of drug release from an immediate release layer was 98.3% were found at the end of 15 minutes followed by sustained the drug release for 12hrs from sustained release layer. The dissolution data were fitted into zero order, first order, Higuchi and Peppas equations. Results revealed that the drug release from the formulation F17 followed zero order kinetics and exhibited Peppas transport mechanism.
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