Optimization of the Gastroretentive Controlled Release Drug Delivery System of Clarithromycin
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 5
Abstract
The The present study investigates the development of an optimized Gastroretentive controlled release drug delivery system. Statistical experimental design and data analysis using response surface methodology is also illustrated. A Box Behnken Design (BBD) was selected and the three factors were evaluated at 3 levels respectively. the amount of HPMC K4M(X1), HPMC E15LV (X2) and sodium bicarbonate (X3) were selected as independent variables and the dependent variables were floating lag time (Y1),T50%(Y2) and T90%(Y3). Fifteen BBD formulations were formulated and dissolution studies and floating characteristics were performed on these formulations. The dissolution data obtained were then fitted to the PCP disso version 2.08 software. Linear regression analysis and model fitting depicted that the formulations followed zero order and Korsmeyer-Peppas kinetic models. The optimized formulation variable was found to be significant for the release properties (P < 0.05) and floating lag time.
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