DESIGN AND IN VITRO EVALUATION STUDIES OF DICLOFENAC SODIUM FLOATING MATRIX TABLETS BY MELT GRANULATION TECHNIQUE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
The purpose of this study was to formulate diclofenac sodium floating matrix drug delivery system by melt granulation technique. These tablets were developed to prolong gastric residence time and increase its bio availability. The diclofenac sodium tablets of 100mg were developed by using different bees wax combinations which are prepared by melt granulation technique by using polymers such as Hydroxy propyl methyl cellulose(HPMC K15M), ethyl cellulose, bees wax alone or in combination with cetyl alcohol, sodium bicarbonate as a gas generating agent and other standard excipients. The prepared granules are subjected to pre compression studies such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio. The optimized formulation produced monolithic tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies, floating lag time indicates that formulations F6 exhibited good and controlled drug release .
Authors and Affiliations
Subramaniyan Chandra, S. Gopi, Biyogo alex, Omarbakri elsayed, Oleti Chandra pavan
Keywords
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- EP ID EP98611
- DOI 10.7897/2230-8407.04531
- Views 114
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