DESIGN, DEVLOPMENT AND EVALUATION OF TRIMETAZIDINE DIHYDROCHLORIDE MODIFIED RELEASE TABLET USING 32 FACTORIAL DESIGN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 10
Abstract
The present investigation was undertaken to fabricate modified release tablet of Trimetazidine dihydrochloride using hydroxypropyl methylcellulose (HPMC) and Ethyl cellulose as a matrixing agent. A 32 full factorial design was employed for the optimization of formulation. The percentage drug released at a given time (Q1, Q2 , Q4,Q8 ,Q 16 , Q24) and the time required for a given percentage of drug to be released (t50%) were selected as dependent variables. The in vitro drug dissolution study was carried out in 1.2 pH , 4.5 pH acetate buffer and 6.8 pH phosphate buffer employing USP Type -1(basket) at 75 rpm. The similarity factor (f2) was calculated for selection of best batch considering mean in vitro dissolution data of marketed product as a reference profile. It is concluded that the desired drug release pattern can be obtained by using a proper combination of HPMC (high gelling ability) and ethyl cellulose (retard drug for longer period of time). The retardation capacity of ethyl cellulose and faster hydration rate of HPMC favors its use in modified release tablets. The matrix integrity during dissolution testing was maintained by using hydroxypropyl methylcellulose2.
Authors and Affiliations
Biswajit Biswal , M. B Patel
Keywords
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