Design, Formulation and Tableting Properties of Aqueous Leaf Extract of Moringa oleifera
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 19
Abstract
Aim: The aim of this study is to formulate a standard dose of aqueous extract of Moringa oleifera leaves into tablets and to determine a suitable binder for the formulation. Methodology: Aqueous extract of Moringa oleifera leaves was extracted and formulated using different binders which included Maize Starch, Gelatin and Micro-crystalline Cellulose (MCC) to find out which one produce better tablets of aqueous extract of Moringa oleifera leaves. Formulations were characterized using various parameters such as physicochemical properties (bulk density, tapped density, moisture content, Hausner’s ratio, Carr’s index, ash value), strength (friability and crushing strength) and release properties (disintegration and dissolution times tests). The result showed that tablets formulated with Gelatin as a binder has lowest friability and disintegration time compared to those formulated with either MCC or maize starch. The crushing strengths were all within the acceptable limit (3 – 6 KgF) except maize starch which was higher. Conclusion: Moringa oleifera tablets were successfully formulated and based on experiments conducted, Gelatin is preferable in the formulation of Moringa oleifera tablets.
Authors and Affiliations
J. Muazu, Z. A. Suleiman
Keywords
Related Articles
- EP ID EP344854
- DOI 10.9734/BJPR/2014/11516
- Views 91
- Downloads 0
Modulatory Effect of Ethanolic Leaf Extract of Annona muricata Pre-treatment on Liver Damage Induced by Dimethylnitrosamine (DMN) in Rats
Aim: This study aim to evaluate the modulatory effect of ethanolic leaf extract of Annona muricata against dimethylnitrosamine (DMN)-induced hepatic toxicity in rats. Methodology: Twenty-four (24) male albino rats divid...
Derivatisation of Cashew Gum by Esterification Using Citric Acid and Glycerol
Citric acid and glycerol were used to derivatise cashew gum via cross-linking. A dispersion of the purified gum, the acid, glycerol and sodium dihydrogen phosphate was made in deionised water and concentrated by heating...
Molecular Typing of Brucella melitensis Isolated from Patients and Animals by Pulsed Field Gel Electrophoresis from Iran
Background: The Brucellosis is recognized as a significant public health problem, with major economic and financial burdens in countries where the disease remains endemic. The disease is one of the most important worldwi...
Biological and Pharmacological Properties of the Sweet Basil (Ocimum basilicum)
Ocimum basilicum L. (sweet basil) a member of Lamiaceae family, is native throughout the old World and cultivated for religious and medicinal purposes. Basil was originated in Asia and Africa. Basil is used in both Ayurv...
Phytochemical Study, Chemicalphysical Analysis and Toxicological Testing of Stem Bark of Dalbergia monetaria L. f.
Aims: Assessing the phytochemical profile, physicochemical and toxicity of crude ethanolic extract of Dalbergia monetaria L. f. against Artemia salina L. Study Design: The study aimed to determine the major classes of se...