Modulatory Effect of Ethanolic Leaf Extract of Annona muricata Pre-treatment on Liver Damage Induced by Dimethylnitrosamine (DMN) in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 3
Abstract
Aim: This study aim to evaluate the modulatory effect of ethanolic leaf extract of Annona muricata against dimethylnitrosamine (DMN)-induced hepatic toxicity in rats. Methodology: Twenty-four (24) male albino rats divided into four (4) groups of six (6) rats each were used for the study. Group 1 served as control and was untreated, group 2 and 3 were pre-treated with 400 mg/kg Annona muricata for one week while group 3 and 4 each received a single oral dose of 20 mg/kg DMN after one week. The rats were sacrificed 48 hrs after DMN administration. Place and Duration of Study: University of Benin and Benson Idahosa University, Benin city, between January and April, 2015. Results: In rats administered 20 mg/kg DMN, Annona muricata pre-treatment at 400 mg/kg body weight significantly reduced the levels of alanine aminotransferase (ALT), aspartate amino-transferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), total cholesterol (TC), triglyceride (TG) and malondialdehyde (MDA) as well as significantly increased reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) compared to DMN-alone administered rats which showed the opposite. Histopathological study in corroborating biochemical analysis also showed significant reduction of liver damage in the rats. Conclusion: Annona muricata significantly restored the antioxidant levels in the liver, counteracted oxidative hepatic dysfunction and exhibited significant protective effect against DMN-induced liver toxicity, which can be mainly attributed to the antioxidant property of Annona muricata.
Authors and Affiliations
Usunobun Usunomena, Okolie P. Ngozi, Eze G. Ikechi
Keywords
Related Articles
- EP ID EP344428
- DOI 10.9734/BJPR/2015/19841
- Views 96
- Downloads 0
Phytochemical Constitutents and Antidiabetic Property of Cola nitida Seeds on Alloxan-Induced Diabetes Mellitus in Rats
The seeds of Cola nitida were investigated for their anti-diabetic properties. The extracts were obtained by maceration in cold water. Alloxan was used to induce diabetes mellitus (DM) in the rats at 180mg/kg body weight...
A Study of the Anticaries Activity of Three Common Chewing Sticks and Two Brands of Toothpaste in South West Nigeria
Aim: To evaluate three common chewing sticks and two brands of toothpaste in south west Nigeria for the ability to control caries-causing bacteria. With an increase in tooth decay and gum diseases all over the world, th...
Impact of Socioeconomic and Risk Factors on Cardiovascular Diseases among People in Bangladesh: A Cross-sectional Health Survey
Aims: The burden of non-communicable diseases especially cardiovascular diseases (CVDs) are rising rapidly in the developing countries particularly in Bangladesh. Therefore, the present study was undertaken to assess the...
Garlic (Allium sativum L.) Protects Hepatic and Renal Toxicity of Alloxan in Rats
Aims: Allium sativum (Garlic) possesses antioxidant principles and is consumed widely as a nutritional agent and for medicinal purposes. This work investigated the effects of aqueous Garlic bulb extract on alloxan-induce...
Comparative Evaluation of Bioactivities of two Marine Sponges, Zygomycale parishii and Callyspongia diffusa from Southwest Coast of India
Aims: The present study was done to evaluate and compare the bioactivities of methanol and dichloromethane extracts of two marine sponges, Zygomycale parishii and Callyspongia diffusa from Southwest coast of India. Place...