DESIGN OF A PHARMACEUTICAL FORMULATION: DEVELOPMENT AND CHARACTERIZATION OF GUATTERIOPSISCINE INCLUSION COMPLEX WITH β-CYCLODEXTRIN
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
The species Guatteria friesiana (W. A. Rodrigues) Erkens & Maas, known as "envireira", is a plant native to Brazil, found particularly in the Amazon region. This plant has important active ingredients, such as the essential oil constituents of leaves and their alkaloids. In other studies, G. friesiana has been shown to have antimicrobial activity, and no cytotoxic effect. In our search for new inhibitors of the acetylcholinesterase enzyme, some alkaloids isolated from G. friesiana were tested in vitro and one of these alkaloids, guatteriopsiscine, showed a promising anticholinesterase activity superior to the standard drug, rivastigmine. However, guatteriopsiscine has a crystalline profile, which suggests a lower solubility in relation to an amorphous compound. Therefore, the search for an efficient and non-toxic carrier for the guatteriopsiscine has important clinical application, the pharmaceutical excipient cyclodextrin can be mentioned as an example of this carrier. This study aimed to obtain and characterize inclusion complexes of guatteriopsiscine with β-cyclodextrin (β-CD). This preparation was done using the technique of malaxation and this characterization was done through several techniques, namely: infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance of hydrogen and tests of dissolution. These techniques confirmed the formation of inclusion complexes between guatteriopsiscine and β-CD. Therefore, the results obtained are promising for the preparation of a future pharmaceutical formulation with that complex.
Authors and Affiliations
Valéria Lima Silva Veras
Keywords
Related Articles
- EP ID EP667353
- DOI -
- Views 159
- Downloads 0
SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): A REVIEW
The oral delivery of lipophilic drugs has a major challenge because of low aqueous solubility of drugs. Improving oral bioavailability of poorly water soluble drugs using self-micro emulsifying drug delivery systems (SME...
PHARMACOKINETICS SURVEILLANCE ON DRUGS- A REVIEW
All drugs can have negative effects. When they reach the market, there are reasonably safe, yet remain in surveillance by pharmacovigilance. Pharmacokinetics plays a very important role in this because we can have monito...
STUDYING THE EFFECT OF RELATIVE HUMIDITY AND COMPACTION PRESSURE ON THE QUALITY OF TABLETS AND PRESSED MASS
This article presents the results of the influence of relative humidity and compaction pressure on the quality of anti-inflammatory tablets “Nimes-S”. According to the data obtained the optimum relative humidity and pres...
IMPLEMENTATION OF A COMMUNITY PILOT CARDIOVASCULAR HEALTH PROGRAM
Mexico is currently suffering from serious problems of obesity based on data from the national survey of health - ENSANUT – 2016[1], shows that 70% of adults aged 30-60 suffer from overweight or obesity, seven in 10 adul...
EFFECT OF ARTESUNATE, ESOMEPRAZOLE AND COFFEE INTAKE ON PRODROMAL PARKINSON’S DISEASE FEATURES IN ADULT MEN
The convergent molecular mechanisms of aging, type 2 diabetes mellitus, Alzheimer’s disease, Parkinson’s disease and Huntington’s disease offer druggable targets. Present drugs for treatment of Parkinson’s disease (PD) o...