DESIGN OF A PHARMACEUTICAL FORMULATION: DEVELOPMENT AND CHARACTERIZATION OF GUATTERIOPSISCINE INCLUSION COMPLEX WITH β-CYCLODEXTRIN
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
The species Guatteria friesiana (W. A. Rodrigues) Erkens & Maas, known as "envireira", is a plant native to Brazil, found particularly in the Amazon region. This plant has important active ingredients, such as the essential oil constituents of leaves and their alkaloids. In other studies, G. friesiana has been shown to have antimicrobial activity, and no cytotoxic effect. In our search for new inhibitors of the acetylcholinesterase enzyme, some alkaloids isolated from G. friesiana were tested in vitro and one of these alkaloids, guatteriopsiscine, showed a promising anticholinesterase activity superior to the standard drug, rivastigmine. However, guatteriopsiscine has a crystalline profile, which suggests a lower solubility in relation to an amorphous compound. Therefore, the search for an efficient and non-toxic carrier for the guatteriopsiscine has important clinical application, the pharmaceutical excipient cyclodextrin can be mentioned as an example of this carrier. This study aimed to obtain and characterize inclusion complexes of guatteriopsiscine with β-cyclodextrin (β-CD). This preparation was done using the technique of malaxation and this characterization was done through several techniques, namely: infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance of hydrogen and tests of dissolution. These techniques confirmed the formation of inclusion complexes between guatteriopsiscine and β-CD. Therefore, the results obtained are promising for the preparation of a future pharmaceutical formulation with that complex.
Authors and Affiliations
Valéria Lima Silva Veras
Keywords
Related Articles
- EP ID EP667353
- DOI -
- Views 120
- Downloads 0
DOES FLUORIDATED MUNICIPAL WATER REDUCE PREVALENCE OF TOOTH CARIES? FLUORIDATED WATER DMFT COMPARED WITH NON-FLUORIDATED DMFT IN THE GREATER MONTREAL AREA: A CLINICAL EPIDEMIOLOGICAL STUDY
Introduction: Various factors moderate oral health and with tooth-decay fluoride in drinking water is important Eufluoride (at 1ppm) is optimal in drinking water to successfully prevent tooth-decay. Higher concentrations...
EDUCATION ON SEXUAL DYSFUNCTION IN PARAPLEGIC MALES
Introduction: Spinal cord injury is a traumatic, life changing event for the injured person. It alters the motor, sensory and autonomic functions, which affects many areas of an individual’s life including his sexual act...
ETHNOPHARMACOLOGICAL PROFILE OF GLORIOSA SUPERBA: AN ENDANGERED MEDICINAL PLANT
Gloriosa superba Linn. (Family: Liliaceae) commonly known as Glory lilly in English and Langali in Hindi, a native of tropical Asia and Africa is one of the drug used by various tribes and communities of India in the tre...
POSTMENOPAUSAL BLEEDING CLINICAL GUIDELINE; RISK AND INVESTIGATION PROSPECTIVE STUDYPOSTMENOPAUSAL BLEEDING CLINICAL GUIDELINE; RISK AND INVESTIGATION PROSPECTIVE STUDY
Postmenopausal uterine bleeding is defined as uterine bleeding after permanent cessation of menstruation resulting from loss of ovarian follicular activity. Bleeding can be spontaneous or related to ovarian hormone repla...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF DIFFERENT SOLVENT EXTRACTS OF SAUSSUREA LAPPA
Antimicrobial efficiency of S.lappa (root extracts) was examined using different kinds of solvents [Methanol, chloroform, and water] and tested against five human pathogens like Bacteria: Bacillus cereus, Staphylococcus...