PREMATURE EVENTS IN CHIKUNGUNYA VIRUS INFECTION AND THEIR INHIBITING STRATEGIES—FROM VIRUS CELL BINDING TO MEMBRANE FUSION
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Chikungunya virus is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world. This infection often leads to an acute self-limited febrile illness with debilitating myalgia and arthralgia. A potential long-term complex infection results severe joint pain, which can last for months to several years. There is no clear-cut mechanistic explanations of the occurrences and spreading of this virus and also still there is no vaccines or specific therapeutics to prevent or treat this infection. Therefore this review describe the latest mechanistic aspects of critical steps involved in chikungunya virus cell entry including cell tropism, virus-receptor binding, internalization and membrane fusion, spreading mechanism and description of the molecules, drugs, other medicinal substances and means that have been used to interfere with the infection and related complications. So the aim of the study is to provide a newer feature on cell entry and to provide a viewpoint on potential new avenues in chikungunya virus research.
Authors and Affiliations
Mohammad Taleb Hossain
COMPARISON BETWEEN MESH VERSUS NON-MESH REPAIR OF INGUINAL HERNIA
Background: Hernias are abnormal protrusions of aviscus (part of it) through a normal or abnormal opening in a cavity (usually the abdomen). They are most commonly seen in the groin; a minority are para-umbilical or inci...
AN OVERVIEW ON NOVEL TRENDS IN ORALLY MOUTH DISSOLVING TABLET
Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Fast diss...
ELECTROCHEMICAL SENSOR BASED ON THE CARBON PASTE ELECTRODE MODIFIED WITH POLYMER FOR DETERMINATION OF COPPER IONS
In this work, we have studied the performance of carbon past electrodes (CPE) coated with £ - caprolactone polymer composites was investigated as an electrochemical sensor in the determination of Cu2+ ions in a 0.1M NaCl...
QUANTIUM THEORICAL ANALYSIS OF MORINGA AND NITROGENOUS BASES OF DNA AND RNA
Moringa (Mo) is used as traditional medicine in different parts of the world. This work aims to treat by theoretical means and using quantum chemistry to show if the main components of this plant work as it has been trie...
RESPIROCYTES: A BOON TO ARTIFICIAL RED BLOOD CELLS
Sub-atomic assembling guarantees exact control of issue at the nuclear and sub-atomic dimension, permitting the development of micron-scale machines involved nanometer-scale segments. Restorative Nanomachines will be amo...