PREMATURE EVENTS IN CHIKUNGUNYA VIRUS INFECTION AND THEIR INHIBITING STRATEGIES—FROM VIRUS CELL BINDING TO MEMBRANE FUSION
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Chikungunya virus is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world. This infection often leads to an acute self-limited febrile illness with debilitating myalgia and arthralgia. A potential long-term complex infection results severe joint pain, which can last for months to several years. There is no clear-cut mechanistic explanations of the occurrences and spreading of this virus and also still there is no vaccines or specific therapeutics to prevent or treat this infection. Therefore this review describe the latest mechanistic aspects of critical steps involved in chikungunya virus cell entry including cell tropism, virus-receptor binding, internalization and membrane fusion, spreading mechanism and description of the molecules, drugs, other medicinal substances and means that have been used to interfere with the infection and related complications. So the aim of the study is to provide a newer feature on cell entry and to provide a viewpoint on potential new avenues in chikungunya virus research.
Authors and Affiliations
Mohammad Taleb Hossain
Keywords
Related Articles
- EP ID EP628063
- DOI -
- Views 154
- Downloads 0
ROLE OF PHARMACIST IN PREVENTION OF MEDICATION ER-RORS IN HOSPITALS AND COMMUNITY SETTINGS
Background: Medication error is currently one of the major public health issues worldwide. This will lead to patient non-compliance to-wards therapy due to adverse drug reactions. The study aims to evalu-ate the most com...
DEVELOPMENT AND VALIDATION OF A SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF ATORVASTATIN IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)
A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. Th...
MONOCLONAL ANTIBIOTICS USAGE IN AUTO IMMUNE DISORDERS
Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies). This process starts by injecting a mouse with an antigen that provokes an immune response. A type...
INVERTASE ACTIVITY OF INTACT SACCHAROMYCES CEREVISIAE CELLS CULTURED IN SUGARCANE MOLASSES BY BATCH FERMENTATION PROCESS
Saccharomyces cerevisiae was cultured by batch fermentation in 2.6L of sugar cane molasses (supplemented with (NH4)2SO4, (5.1g/L), MgSO4.7H2O (75mg/L) and Na2HPO4.12H2O (2.4g/L); concentration of reducing sugars (RS) and...
ROLE OF POLYOLS AND SURFACTANTS IN LIQUID PROTEIN FORMULATIONS
in aqueous protein formulations, increase conformational stability of proteins by size exclusion mechanism, increasing thermodynamic stability of proteins and decreasing aqueous solubility. Polyols prevent protein aggreg...