MONOCLONAL ANTIBIOTICS USAGE IN AUTO IMMUNE DISORDERS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 1
Abstract
Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies). This process starts by injecting a mouse with an antigen that provokes an immune response. A type of white blood cell, the B cell that produces antibodies that bind to the antigen are then harvested from the mouse. These isolated B cells are in turn fused with immortal B cell cancer cells, a myeloma, to produce a hybrid cell line called a hybridoma, which has both the antibody-producing ability of the B-cell and the exaggerated longevity and reproductively of the myeloma. Once monoclonal antibodies for a given substance have been produced, they can be used to detect the presence of this substance. The Western blot test and immuno dot blottests detect the protein on a membrane. They are also very useful in immunohistochemistry, which detect antigen in fixed tissue sections and immunofluorescence test, which detect the substance in a frozen tissue section or in live cells. Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to certaincells or proteins. This may then stimulate the patient's immune system to attack those cells. Monoclonal antibodies used for autoimmune diseases include infliximab and adalimumab, which are effective in rheumatoid arthritis, Crohn's disease and ulcerative Colitis by their ability to bind to and inhibit TNF-α. Basiliximab and daclizumab inhibit IL-2 on activated T cells and thereby help preventing acute rejection of kidney transplants. Omalizumab inhibits human immunoglobulin E (IgE) and is useful in moderate-to-severe allergic asthma.
Authors and Affiliations
Praneeth Chandaluri
Keywords
Related Articles
- EP ID EP617577
- DOI -
- Views 172
- Downloads 0
THE EFFICACY OF CHITOSAN NANOPARTICLE ALONE VERSUS CONJUGATED WITH Nigella sativa (EL BARAKA SEED OIL) AGAINST Cryptosporidium parvum IN INFECTED IMMUNOCOMPETENT AND IMMUNOSUPPRESSED MICE
Cryptosporidium is a protozoan parasites that affect the gastrointestinal epithelium and other mucosal surfaces of their hosts, which include humans and domestic and wild animals worldwide. Current diagnostic methods inc...
PHYSICAL CHARACTERISTICS OF RESERVOIR TYPE PATCH USING NANOSTRUCTURED LIPID CARRIERS (NLC) AS DRUG RESERVOIR, HPMC 606 AS RATE CONTROLLING MEMBRANE AND MELOXICAM AS DRUG MODEL
The purpose of this research work was to create a meloxicam patch transdermal drug delivery system using Nanostructured Lipid Carriers (NLC) as drug reservoir and Hydroxy Propyl Methyl Cellulose (HPMC) as rate controllin...
CONCEPTUAL STUDY OF OBESITY AND ITS MANAGEMENT BY AYURVEDA
Obesity is a multi-factorial metabolic disorder occupying major share in today’s life style disosrder. According to WHO India is the third most obese country of the world, the prevalence of obesity is higher in urban pop...
FLOATING MICROSPHERES: A REVIEW
The real challenge in the development of an oral drug delivery system is not only to sustain the drug release but also to extend the presence of the dosage form within the gastrointestinal tract until all the drug is com...
A REVIEW: FIXED DOSE COMBINATIONS OF PENICILLINS
A combination drug is a fixed dose combination (FDC) that includes two or more active pharmaceuticals ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses. Antibiotics...