Design of Peptide Models for β-Hairpins and Equilibrating Helix-Hairpin Structures
Journal Title: International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Year 2016, Vol 2, Issue 1
Abstract
It is well established that synthetic peptides containing a centrally positioned Type-I or Type-II β-turn can form well folded peptide hairpins (1). Earlier studies from this laboratory have established that D-Pro-Xxx segments nucleate β-hairpin structures, with formation of a central Type-II β-turn (2). The octapeptide (Boc-Leu-Phe-Val-Aib-D-Ala-Leu-Phe- Val-OMe) is a rare example of a synthetic peptide hairpin, containing a central Type-I β-turn. Hairpins with Type-I turns are considerably more twisted than their Type-II counterparts. The Aib-Xxx segment has also been shown to adopt a Type-I β-turn structure, resulting in incorporation into the centre of a long synthetic, helical peptide (3) (Figures 1,2).
Authors and Affiliations
Selvakkumar Chinnasamy, Reddy Eashwarwark Vikram, Selvarajan Kesavanarayanan Krishnan, Rahamuthullah Nazeerullah, Zarmouh Muftha Mohamed
Synthesis, Characterization and Imaging of Fluorescine Isothiocyanate Conjugated Magnetite Nanoparticles in MCF 7 Breast Cancer Cell Lines
In this work we describe fabrication, characterization and possible application of FITC (fluorescine isothiocyanate) conjugated magnetite nanoparticles (MNPs) for biomedical applications such as imaging of cancer cells....
Prediction of Enhanced Dimerization inside Dilute Alloy Nanoparticles
According to a unique nano-confinement effect of entropic origin, predicted by us several years ago for the equilibrium state of chemical reactions, the equilibrium-constant and extent are greatly enhanced depending on t...
Highly Monodisperse Chitosan Nanoparticles Prepared by a Combined Triple-Method for Potential Use as Drug Carriers
Chitosan (CS) as a biodegradable polymer with unique bio-attachment properties that makes it favorable to be used in biomedical applications. Insolubility in water is the problem with use of CS. The purpose of this study...
Surface Enhanced Raman Scattering Spectroscopy for Pharmaceutical Determination
The rapid growth of pharmaceutical industries worldwide demands continuous development of efficient analytical techniques that help not only to detect the presence of the molecules at extremely low concentration levels,...
Preparation of nanocellulose and its potential application
Nanostructured cellulose has received tremendous attention due to its inherent unique properties such as high strength, high surface area, flexible surface chemistry, abundant and renewable. The early polymers industry w...