Design, prediction of bioactivity by physicochemical parameters and Synthesis of Schiff bases of 8-Amino chromone derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 7
Abstract
Drug-design and synthesis leading to the Drug discovery is the area of thirst today. The prediction of the bioassay of the drug before synthesis is treated as the novel approach in drug design. Chromones have drawn the attention of many pharmacologists because of their good biological activities like anti-cancer, antioxidant, antimicrobial, antibiotic, anti HIV, and as good vasodilators and were preferred due to their less mammalian toxicity. In this paper, the authors presented the synthesis and antimicrobial activities of Schiff bases of some chromones. The Schiff base is an important class of chemicals which acts as good intermediates for synthesis of many drugs. Schiff bases of 8-amino-7-hydroxy-2 methyl (or phenyl)-3-methyl chromones 4(ad) with a series of selected aldehydes 5(a-c) were synthesized. The synthesized compounds 8- ((phenylimino)methyl)-7-hydroxy-3-methyl-2-phenyl)-4H-Chromen-4-one, 6(a-l) were formed. The newly synthesized compounds were characterized by spectral analysis like IR, NMR and Mass spectrometry.
Authors and Affiliations
Jyothi H. Kini, Vasantakumar K. Pai, Yadav D. Bodke
Keywords
Related Articles
- EP ID EP414333
- DOI 10.9790/5736-1107020108.
- Views 144
- Downloads 0
Characterisation and solubility studies of Quinine sulphate and Hydroxychloroquine sulphate inclusion complexes with α – cyclodextrin
Cyclodextrins are cyclic oligo saccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives generate a hydrophilic exterior surface and a non -...
Comparing Synthesis Approach of Two Hybrid Nanoparticles Encapsulating Paraffin Wax
Many innovative concepts and models are being considered to make Nano fluid technology more and more efficient and cost effective. In this article we have illustrated the synthesis process of hybrid nanoparticles which e...
Chemical Analysis of Metal Content In Water of Son River In District Sidhi of madhya Pradesh India
The Present research work undertaken for Chemical Analysis of metal content in water of Son River of district Sidhi during mansoon, winter and summer season in the year 2016-17 where metals such as calcium, magnesium, po...
The Effect of pH on formation of Demi-macrocycles of N2O2 with complexes Cr (II) Fe (II) and Co (II) ions”
The kinetic measurements was carried out under pseudo first-order conditions are followed in different pH range kinetic integration and graphical method at different pH range 6.55, 7.0 and 9.2 at constant acetate buffer...
Formulation and Characterization of Self Emulsifying Drug Delivery System of Simvastatin Using Maringa Oleifera and Banished Oil Extract For Potential Pharmaceutical Application
Poor aqueous solubility of some chemical entities presents a major challenge to modern drug delivery. Self emulsifying drug delivery systems (SEDDS) have gained exposure for their ability to increase solubility and bioav...