DESIGN, SYNTHESIS AND ANTIEPILEPTIC EVALUATION OF 5-(ARYL)-N-PHENYL-1,3,4-THIADIAZOL-2-AMINE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2012, Vol 4, Issue 3
Abstract
Epilepsy is one of the leading neurological disorders, which is a major threat to public health. Though, several new antiepileptic drugs are developed, the treatment of epilepsy remains still inadequate, and the patient suffers from a lot of side effects. Therefore, it is essential to search for newer chemical entities for the treatment of epilepsy. So here an indirect type of molecular modeling study was carried out to find out the 3D structural similarity between some reported antiepileptic drugs and the newly designed 1,3,4-thiadiazole derivatives. Thus, a new series of 1,3,4-thiadiazole derivatives were synthesized by cyclization of N-phenylthiosemicarbazide with various aromatic acids. Both conventional and microwave irradiated synthesis of 1,3,4-thiadiazole derivatives have been carried out to compare their yield and reaction time. Microwave technology enables the reaction to be simple, rapid, high yielding with at most pure and led environmentally benign synthesis. All the newly synthesized compounds were characterized by I.R, 1H NMR, and LC-MASS and also evaluated for their antiepileptic activity by MES model in rats.
Authors and Affiliations
BISWA MOHAN SAHOO , S. C. DINDA , B. V. V. RAVI KUMAR
Keywords
Related Articles
- EP ID EP125052
- DOI -
- Views 148
- Downloads 0
STUDY OF THE INCLUSION BEHAVIOUR OF Î’-CYCLODEXTRIN WITH ZIPRASIDONE AND ITS PHARMACEUTICAL APPLICATION
The inclusion complex of the slight water solubility ziprasidone (ZIP) with β-cyclodextrin (β-CD) was investigated by spectrofluorimetry. Influence of pH and β-CD concentration on the fluorescence spectra was reported...
SIMULTANIOUS DETERMINATION OF ANTIRETROVIRAL DRUGS EMTRICITABINE AND TENOFOVIR DESOPROXIL FUMERATE BY A STABILITY INDICATING RP-HPLC METHOD
Objective: The objective of the present investigation is to develop a stability indicating RP-HPLC method for the simultaneous estimation of Emtricitabine (EMT) and Tenofovir Desoproxil Fumerate (TDF) in pure and tablet...
IN SILICO DOCKING STUDIES ON KAEMPFERITRIN WITH DIVERSE INFLAMMATORY AND APOPTOTIC PROTEINS FUNCTIONAL APPROACH TOWARDS THE COLON CANCER
Objective: The objective of this research was to formulate the binding energies and interaction of amino acid residues in kaempferitrin with different types of apoptotic and inflammatory proteins of colon cancer.Methods:...
POPULATION PHARMACOKINETICS OF CONTINUOUS INFUSION OF FACTOR VIII IN HEMOPHILIA-A PATIENTS UNDERGOING ORTHOPEDIC SURGERY
Objective: to develop a population pharmacokinetic model taking into account blood losses during and after orthopedic surgery in adult hemophilia A patients receiving infusion of coagulation factor VIII, and to evaluate...
NOVEL GASTRO-RETENTIVE POLYMERIC MICROSPHERES: AN APPROACH FOR INCREASED BIOAVAILABILITY AND AN ONCE DAILY DOSING OF TERBUTALINE SULPHATE
Objective: The purpose of this study was to develop multi-unit alginate-copolymer adhesive microspheres to achieve a sustained release of terbutaline sulphate (TBS) and overcome the hepatic first pass effect so as to enh...