DESIGN, SYNTHESIS AND ANTIEPILEPTIC EVALUATION OF 5-(ARYL)-N-PHENYL-1,3,4-THIADIAZOL-2-AMINE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2012, Vol 4, Issue 3
Abstract
Epilepsy is one of the leading neurological disorders, which is a major threat to public health. Though, several new antiepileptic drugs are developed, the treatment of epilepsy remains still inadequate, and the patient suffers from a lot of side effects. Therefore, it is essential to search for newer chemical entities for the treatment of epilepsy. So here an indirect type of molecular modeling study was carried out to find out the 3D structural similarity between some reported antiepileptic drugs and the newly designed 1,3,4-thiadiazole derivatives. Thus, a new series of 1,3,4-thiadiazole derivatives were synthesized by cyclization of N-phenylthiosemicarbazide with various aromatic acids. Both conventional and microwave irradiated synthesis of 1,3,4-thiadiazole derivatives have been carried out to compare their yield and reaction time. Microwave technology enables the reaction to be simple, rapid, high yielding with at most pure and led environmentally benign synthesis. All the newly synthesized compounds were characterized by I.R, 1H NMR, and LC-MASS and also evaluated for their antiepileptic activity by MES model in rats.
Authors and Affiliations
BISWA MOHAN SAHOO , S. C. DINDA , B. V. V. RAVI KUMAR
Keywords
Related Articles
- EP ID EP125052
- DOI -
- Views 160
- Downloads 0
EFFECT OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN-II RECEPTOR BLOCKERS ON PROTEINURIA OF HYPERTENSIVE PATIENTS IN STANDARD CARE PRACTICE
Objective: This study investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin-ii receptor blockers (ARBs) on protein creatinine index (PCI) of patients with hypertension in a standard...
ROLE OF NORMAL PERFUSION TIME ON FUNCTIONAL ENZYME ACTIVITIES AND PHYSIOLOGY OF INTERFIBRILLAR AND SUB-SARCOLEMMAL MITOCHONDRIA FROM ISOLATED RAT HEART
Objective: Obvious lack of interfibrillar mitochondria (IFM) subpopulation in isolated mitochondria attributed to limitations in the isolation procedure. In this manuscript, we compared the functional activities of mitoc...
CALLUS INDUCTION AND DIRECT ORGANOGENESIS IN SAFFRON CALLUS BY USING PLANT EXTRACT AS AN ALTERNATIVE TO PHYTOHORMONES
Objectives: Saffron (Crocus sativus) is mostly propagated vegetatively. Therefore, cost-effective methods need to be developed, in order to multiply and increase the yield of saffron. The aim of present study was to use...
DRUG UTILIZATION STUDY AND EVALUATION OF ANTI-HYPERTENSIVE PRESCRIPTIONS FROM MEDICAL REIMBURSEMENT APPLICATIONS AT UNIVERSITY HEALTH CARE FACILITY, BHU, VARANASI
Objective: Pharmacoeconomics evaluates the relationship between clinical, economic, and humanistic outcome for maximizing the value for each monetary unit spent on product and services. So the objective of the study was...
A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LORNOXICAM AND DICLOFENAC AS POSTOPERATIVE ANALGESICS AFTER MASTOIDECTOMY SURGERY
Objective: The objective of the research was to evaluate the efficacy and safety of lornoxicam compared to diclofenac in the management of postoperative pain following mastoidectomy surgery. Methods: The present study wa...