DESIGN, SYNTHESIS AND ANTIEPILEPTIC EVALUATION OF 5-(ARYL)-N-PHENYL-1,3,4-THIADIAZOL-2-AMINE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2012, Vol 4, Issue 3
Abstract
Epilepsy is one of the leading neurological disorders, which is a major threat to public health. Though, several new antiepileptic drugs are developed, the treatment of epilepsy remains still inadequate, and the patient suffers from a lot of side effects. Therefore, it is essential to search for newer chemical entities for the treatment of epilepsy. So here an indirect type of molecular modeling study was carried out to find out the 3D structural similarity between some reported antiepileptic drugs and the newly designed 1,3,4-thiadiazole derivatives. Thus, a new series of 1,3,4-thiadiazole derivatives were synthesized by cyclization of N-phenylthiosemicarbazide with various aromatic acids. Both conventional and microwave irradiated synthesis of 1,3,4-thiadiazole derivatives have been carried out to compare their yield and reaction time. Microwave technology enables the reaction to be simple, rapid, high yielding with at most pure and led environmentally benign synthesis. All the newly synthesized compounds were characterized by I.R, 1H NMR, and LC-MASS and also evaluated for their antiepileptic activity by MES model in rats.
Authors and Affiliations
BISWA MOHAN SAHOO , S. C. DINDA , B. V. V. RAVI KUMAR
Keywords
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