Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 1
Abstract
Thiadiazole derivatives are reported to have various biological activities including antihyperlipidemia In the present study a series of Nphenyl1 3 4thiadiazol2amine derivatives were designed using various softwares like Molinspiration Schrodinger etc The derivatives with optimum properties were synthesized and characterized using FTIR 1HNMR and MASS spectroscopy In vivo screening for antihyperlipidemic activity in triton X100 induced models showed moderate activity in comparison with standardKeywords Thiadiazole Antihyperlipidemia Triton X100 Atorvastatin
Authors and Affiliations
Paul Jacob, Beena Thomas, Neethu Santhosh
Keywords
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- EP ID EP481422
- DOI 10.18231/2394-2797.2018.0004
- Views 105
- Downloads 0
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