Synthesis and antimicrobial activities of some novel thieno [2,3-d]- Pyrimidin-4(3H)-One derivatives
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 2
Abstract
Pain and inflammation are simultaneous responses in bacterial infections In current clinical practice the agents like antimicrobial drug are prescribed concurrently A POCl3 catalyzed efficient onestep and solventfree synthesis of novel thieno 2 3d pyrimidin43Hone derivatives from 2amino45substitutedthiophene3carbonitrile has been developed using various aliphatic acid under conventional heating and microwave irradiation The formation of compounds was confirmed using elemental analysis and spectroscopic techniques like FTIR 1H NMR and Mass spectroscopy All synthesized compounds have been screened for their antimicrobial activity against Escherichia coli Gram ve strain Bacillus subtilis Gram ve strain for antibacterial activity and antifungal activities against Aspergillus niger and Candida albicans The result showed that synthesized compounds exhibit weak moderate and good antimicrobial activity It was observed that the compounds 2a 2c 2d 2e 2f 2g 2j and 2k showed good antimicrobial activity whereas compounds 2b 2i 2j showed significant antimicrobial activity compared with standard drug Streptomycin and Amphotericin B respectivelyKeywordPOCl3 Thieno2 3dpyrimidin4 3Hone Antimicrobial activity Streptomycin and Amphotericin B
Authors and Affiliations
D. P. Kawade, A. V. Hadke
Keywords
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- EP ID EP481435
- DOI 10.18231/2394-2797.2018.0010
- Views 42
- Downloads 0
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