DESIGN, SYNTHESIS AND DOCKING STUDY OF PYRIDINE DERIVATIVE FOR ANTIDEPRESSANT ACTIVITY
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
On the basis of literature survey compound 2-(1H-benzo[d]imidazole-1-yl)-N-(3-cyano-4,6-diphenylpyridin-2-yl) acetamide (6) was designed. Compound 6 and imipramine were virtually studied for their antidepressant activity by performing docking studies using Molegro Virtual Docker (MVD-2013, 6.0) on human MAO (PDB ID: 2BXS). Docking studies revealed its potential antidepressant effect as compared with imipramine. The result of docking study was validated by synthesizing and screening the compound for it’s in vivo antidepressant activity following forced swim test and locomotor activity using actophotometer. Finally, we conclude that the docking result and experimental results are in good agreement.
Authors and Affiliations
Mitali M Naik
Keywords
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