DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDY OF HYBRID QUINOLINE-4-YL-OXADIAZOLES/OXATHIADIAZOLES AS POTENT ANTIFUNGAL AGENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The aim of the present work was to design and synthesize hybrid quinoline-4-yl-oxadiazoles/oxathiadiazole derivatives and evaluate them for in vitro antifungal activity against human disease causing pathogens.Methods: The compounds 5(a-d), 6(a-d) and 7(a-d) were efficiently synthesized in good yields. The synthesized compounds were characterized using 1H NMR, 13C NMR and Mass spectra. The synthesized compounds were screened for in vitro antifungal activity and minimum inhibitory concentration (MIC) values were determined using standard agar method. Molecular docking study was performed against fungal enzyme P450 cytochrome lanosterol 14α-demethylase using VLife MDS 4.3 software.Results: The synthesized compounds had shown good to moderate in vitro antifungal activity. The compound 6a (MIC range = 15-25 µg/ml) from 1,2,3,5-oxathiadiazole-2-oxide series showed most potent activity amongst the synthesized compounds when compared with standard clotrimazole (MIC range = 12.5-25 µg/ml). The molecular docking study of synthesized compounds showed good binding interactions against active site of fungal enzyme P450 cytochrome lanosterol 14α-demethylase.Conclusion: The results of in vitro antifungal activity and molecular docking study revealed that the synthesized compounds have potential antifungal activity and can be further optimized and developed as a lead compound.Â
Authors and Affiliations
Firoz A. Kalam Khan, Jaiprakash N. Sangshetti
Keywords
Related Articles
- EP ID EP578874
- DOI -
- Views 90
- Downloads 0
DEVELOPMENT AND VALIDATION OF HPLC/UV METHOD FOR DETERMINATION OF MELOXICAM IN HUMAN PLASMA AND APPLICATION IN PHARMACOKINETIC STUDIES
Objective: To develop and validate a modified isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method for determination of Meloxicam in human plasma to be used for pharmacokinetic...
FORMULATION AND IN-VITRO EVALUATION OF MOXIFLOXACIN OCULAR INSERTS
Objectives: Most ocular diseases are treated with topical applications of eye drops. After instillation of an eye drop, typically less than 5 % of the applied drug penetrates the cornea and reaches intraocular tissues, w...
IMPACT OF LIFESTYLE ON THE OCCURRENCE OF ANXIETY AMONGST THE RESIDENTS OF UNITED ARAB EMIRATES
Objective: To investigate the effect of lifestyle on the occurrence of anxiety. Also, to study the determinants of the severity of anxiety.Methods: A cross-sectional survey was carried out on 100 randomly selected partic...
ISOLATION AND CHARACTERIZATION OF MDR BACTERIA FROM IN VITRO CULTURE OF BACOPA MONNIERA AND SUPPLEMENTATION OF NATURAL EXTRACTS TO CONTROL BACTERIAL CONTAMINATION
Objective: The purpose of the present study was to isolate and characterize bacterial contamination from in vitro culture of Bacopa monniera callus culture.Methods: The two selected isolates (1 and 2) were identified by...
EFFECTS OF STREPTOZOTOCIN INDUCED DIABETES MELLITUS TYPE 1 ON THE RAT BRAIN ANTIOXIDANT STATUS AND ACTIVITY OF ACETYL-CHOLINESTERASE: A NOVEL AND POTENTIAL TREATMENT BY VITEX NEGUNDO.
Objective: The objective of the present study was to determine the effect of streptozotocin (STZ) induced diabetes type 1 on activity of acetyl-cholinesterase (AChE) in rat brain and on the brain antioxidant status and a...