Detection of Metastatic Lung Cancer by Immunocytochemistry and Flow Cytometry in a Sample of Pleural Fluid
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2016, Vol 7, Issue 3
Abstract
Malignant pleural effusions (MPE) are common complications in cancer patients and indicate the spread of the primary disease (metastasis). For over a century, malignant effusion has been diagnosed through the observation of changes in the cavity effusion cells, such as the gold-standard cytomorphological analysis. Studies show that the multiparameter flow cytometric analysis is sensitive and rapid and allows for the immunophenotypic evaluation of a large number of cells. This report describes the case of a 64-year-old man diagnosed with lung cancer who had never had any kind of treatment for this disease. The pleural sample was analyzed by morphological (quantitative and differential cytology) and immunocytochemical analyses. As a new tool for diagnosis of malignant pleural effusion, the sample was also analyzed by flow cytometry. In the case report described, flow cytometry was an effective and quick method for detecting neoplastic cells in pleural fluids.
Authors and Affiliations
Manoela Lira Reis, Rafaela Pilon, Aline Costa, Teresa Maria da Silva Figueiredo, Alisson Bigolin, Ana Carolina Rabello de Moraes, Renata Cristina Messores Rudolf de Oliveira, Maria Cláudia Santos da Silva
Keywords
Related Articles
- EP ID EP328350
- DOI 10.9734/IJMPCR/2016/26726
- Views 79
- Downloads 0
Giant Cell Fibroma: A Case Report Concerning an Unusual Lesion of the Oral Cavity
Aims: We describe the case of a young man with giant cell fibroma (GCF) of the oral cavity. Cases such as this are rare and we believe that our research adds to the literature concerning this area of study. Presentation...
Cerebellar Blastomycosis in an Immunocompetent Patient: A Case Report
Blastomycosis is a fungal infection that mostly involves the skin and lung with only a 5-10% incidence of Central nervous system involvement [1]. It occurs worldwide but it is endemic to areas like the Midwestern United...
Gorlin Goltz Syndrome – A Case Report from Bosnia and Herzegovina
Gorlin-Goltz syndrome (GGS) is an uncommon inherited disorder characterized by numerous basal cell carcinomas, odontogenic keratocysts and musculoskeletal malformations. A spectrum of other neurological, ophthalmic, endo...
Unusual Cause of Rhabdomyolysis Causing Acute Renal Failure: Achillea millefolium and
Introduction: Rhabdomyolysis is a frequent disorder resulting from many different causes which may be apparent from the history, e.g. trauma, heavy exercise, intoxications. It contains both clinical and biochemical compo...
Implementing the Use of Ultrasonography Screening Markers of the Trisomy 18 in the Clinical Practice, in the Era of Non-invasive Prenatal Test: Case Reports
Introduction: Edwards’s syndrome (Tr18) is a genetic disorder caused by trisomy of the chromosome 18, and its penetrance is cc. 1:5000. This Edwards-syndrome or trisomy18 associated with many different conditions and abn...