Tyrosine Kinase Inhibitor Induced Pulmonary Artery Hypertension: Reversible with Ponatinib?
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2017, Vol 9, Issue 3
Abstract
Pulmonary arterial hypertension (PAH) is a disease associated with progressive and comprehensive vascular remodeling of small pulmonary arteries. The prognosis of Chronic myelogenous leukemia (CML) has been improved by tyrosine kinase inhibitors (TKIs), which inhibit BCR/ABL kinase pathway. Most of the TKIs induced PAH is limited almost exclusively to dasatinib until now. There was only one report about, PAH was caused by the novel TKI ponatinib. We present a 73 years old-female patient with chronic myeloid leukemia, who had PAH after approximately 72 months with prior exposure to dasatinib. Dasatinib was replaced by nilotinib in this patient. Nilotinib was used 11 months for CML treatment, but no recovery was seen with also this TKI. Finally, ponatinib therapy was started for CML. Signs and symptoms of PAH improved with institution of ponatinib therapy. Therefore we report that the patient with dasatinib induced PAH did not recover after institution of nilotinib as a TKI instead of dasatinib but improved with ponatinib treatment using for CML.
Authors and Affiliations
Serkan Gokaslan, Ersel Onrat, Cigdem Özer Gokaslan, Ibrahim Etem Dural
Keywords
Related Articles
- EP ID EP309651
- DOI 10.9734/IJMPCR/2017/34110
- Views 110
- Downloads 0
Mucinous Neoplasm of the Appendix – An Incidental Histopathologic Finding after Appendectomy Due to the Acute Appendicitis – Case Report
This paper presented a case of a male patient, who was referred from the gastroenterology unit to our department for an emergency surgery due to an acute appendicitis with suspected perforation as shown on the abdominal...
A Case of Gastric and Esophageal Perforation Caused by Endoscopic Retrograde Cholangiopancreatography
Aim: Endoscopic retrograde cholangiopancreatography (ERCP) is no longer in use as a diagnostic procedure but rather when a therapeutic intervention is needed or most likely to be needed depending on the pre-ERCP imagings...
Anesthetic Management of a Pregnant Woman with Limb-girdle Muscular Dystrophy in the Caesarean Section: A Case Study
In a study, we present the case of a 33-year-old obese patient with limb-girdle muscular dystrophy (LGMD) admitted for cesarean section. The patient was successfully managed by emergency caesarean section under spinal an...
Using Pazopanib and Radiotherapy to Treat Metastatic Renal Cell Carcinoma with Acrometastases
Introduction: Renal cell carcinoma (RCC) is the third most common urological cancer. Skeletal metastases from renal cell carcinoma are common, but metastatic tumors involving the hand and foot are rare. This is known as...
Hereditary Juvenile Haemochromatosis and Idiopathic Dilated Cardiomyopathy
Hereditary hemochromatosis (HH), a common autosomal recessive disease, is characterized by excessive iron overload/toxicity in multiple organs (joints, liver, heart, pancreas, pituitary, adrenals and skin). Symptoms and...