Detection of subclinical hypothyroidism in children with epilepsy on valproate monotherapy in age group of 3-12 years
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: Sodium valproate is an effective anti-epileptic drug and is commonly used in the treatment of childhood epilepsy .There are conflicting reports in the literature about the influence of valproate on thyroid function. Elevated TSH levels have been demonstrated in a few studies but not all. Therefore, the present study was planned to detect sub clinical hypothyroidism in children in the age group of 3-12 years with epilepsy on valproate monotherapy. Materials and Methods: 100 newly diagnosed children with epilepsy aged between 3 to 12 years receiving valproate monotherapy were enrolled in this study. An equal number of age and sex were matched controls were also included in the study. Thyroid Profile was done by Competitive enzyme immunoassay. FT4 and TSH values were compared before starting valproate and after 6 months of receiving the drug. Results: A significant difference was observed in mean FT4 values between the epileptic and the control groups On the other hand, TSH values did not show any significant difference between the two groups. A significant increase in TSH values (p value < 0.0001) was observed in patients of epilepsy before (1.98 + 0.93) and after (4.5 + 2.81) treatment thus showing that valproate alters the thyroid hormone levels causing subclinical hypothyroidism.
Authors and Affiliations
Sunil Ranga, Charanjeet Ahluwalia, Harini D, I P Choudhry, K C Aggarwal
Keywords
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