Determination and Validation of RP-HPLC Method for the Estimation of Fosamprenavir in Tablet Dosage Form
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2023, Vol 7, Issue 4
Abstract
A new simple, accurate, profitable, rapid-fire and precise rear phase high performance liquid chromatographic system has been developed for the validated of Fosamprenavir in bulk form and its pharmaceutical lozenge form. Chromatographic separation was carried out on Zorbax C mm mm m Make X terra 18 4.6 X 250 , 5 , ( ) column using a admixture of Acetonitrile Methanol Water (503020 v/ v) as the mobile phase at an inflow rate of1.0ml min , the discovery was carried out at 265nm. The retention time of the Fosamprenavir was set up to be5.462 0.02 ± min . The system was validated according to ICH guidelines for linearity, perceptivity, delicacy, perfection, particularity and robustness. The response was set up to be direct in the medicine attention range of 50 90 − mcg ml for Fosamprenavir. The correlation measure was set up to be 0.999. The LOD and LOQ for Fosamprenavir were set up to be 1.6µg ml and 4.8µg ml independently. The proposed system was set up to be good chance recovery for Fosamprenavir, which indicates that the proposed system is largely accurate. The system perfection for the determination of assay was below 2.0 RSD. The system is useful in the quality control of bulk and retailed pharmaceutical phrasings
Authors and Affiliations
Karnakar N*, Srinivasa RA, Kishore AVB, Ramana H, Amani P, Ramesh
Keywords
Related Articles
- EP ID EP751863
- DOI 10.23880/oajpr-16000292
- Views 30
- Downloads 0
An Updated Review on Self Emulsifying Drug Delivery System
Solubility of orally administered drug is major obstacle of pharmaceutical industry as nearly 35-40% of newly discovered drugs substancehave low aqueous solubility which results in their poor dissolution and bioavailabi...
A Review on Self Emulsifying Nanoemulsion
Current article is focused on recent advances in the formulation and characterization of Self Emulsifying Nanoemulsions in Drug Delivery. Self-Emulsifying Drug Delivery Systems (SEDDS) are the isotropic mixtures of oil,...
HPLC Method Development and Validation: For Simultaneous Determination of Flibanserin and Caffeine
A simple and rapid HPLC method is developed and validated for the simultaneous determination of Flibanserin and Caffeine. This is the first single reported method for these two drugs. The good separation was achieved by...
Antidiabetic Activity of Pereskia Bleo Aqueous Extracts in Alloxan Induced Diabetic Rats
Pereskia bleo Kunth (Cactaceae) is locally known as ‘Jarum tujuh bilah’. It has been used traditionally by local Malays for the treatment of diabetes. This study investigates the antidiabetic activity of aqueous extract...
Analgesic and Anti-inflammatory Properties of Argyreia Pilosa Wight & Arn
Background: Pain and inflammation are usually related to the pathophysiology of several medical conditions. The majority of antinociceptive and anti-inflammatory medications accessible within the merchandise found an out...