Insights into the Effect of Trehalose and Cyclodextrin Molecules on Dissolution Characteristics of Furosemide Lyophilised Powder
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2020, Vol 4, Issue 2
Abstract
The aim of this work is to enhance the dissolution of furosemide, a hydrophobic drug used in treating hypertension. Solid dispersion via lyophilisation was employed for this purpose. Sugar and oligosaccharide, trehalose and hydroxyl propylγ-cyclodextrin (HP-γ-CD), were used as carrier molecules. Complexation of drug molecules with cyclodextrins changes its physical properties, including solubility. Trehalose was selected as it is a hydrophilic molecule as well as it reduces the cellular oxidative stress. Binary solid dispersions at three weight ratios drug to sugar/oligosaccharide were prepared. Solid dispersions were compared with unprocessed drug molecules and the marketed product. Samples were characterized via Fourier transform infrared spectroscopy, differential scanning calorimetry and In vitro drug dissolution. All lyophilized samples showed a significant improvement (p < 0.05) in furosemide dissolution in the aqueous dissolution medium. The study introduces furosemide/HP-γ-CD and furosemide/trehalose freeze dried composites as potential candidate powders to formulate for example fast disintegrating tablets.
Authors and Affiliations
Saleh A, Elkordy AA*, Chaw CS, McGarry K and Essa EA
Keywords
Related Articles
- EP ID EP748463
- DOI 10.23880/oajpr-16000205
- Views 32
- Downloads 0
In-Vivo Toxicity Assessment of Stem Bark Extracts of Spondias mombin (Linn) on Male and Female Albino Rats
Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female...
CDP-Choline Effect on Arthritis Model in Rat
CDP-choline is a naturally occurring endogenous nucleotide, which after administration rapidly metabolizes to choline (which is a natural α7nAChR selective Agonist) and cytidine/uridine. In the body, Choline promotes sev...
A Review on Wound Healing
In spite of the incredible progress in human medicine, infectious diseases caused by bacteria, fungi, viruses and other parasites are still a major risk to public health. Since ages, plants and herbs with wound healing,...
The Evolving Definition of Comparative Effectiveness Research: Lessons for Researchers Planning and Designing a Clinical Development Program
Among the many challenges that must be overcome in successfully developing a novel drug treatment is to understand and prepare evidence that will ultimately be required by regulators and reimbursement authorities. Payers...
Assessment of Self-Medication and Disease Awareness about Migraine in Local Community of Multan, Pakistan
Background: Self-Medication and Poor disease awareness of Migraine is the furthermost public well-being concern in many countries, as well as in Pakistan. Thus considering the current epidemiological evidence about that...