Determination of alkaloids amount from Iranian Papaver bracteatum Lindl. by HPLC
Journal Title: Journal of Herbal Drugs - Year 2011, Vol 2, Issue 1
Abstract
Background & Aim: Papaver bracteatum Lindl. (Papaverace) is an important pharmaceutical plant which contains isoqinoline alkaloids. Isoqinoline alkaloids constitute one distinct group of secondary metabolites of the Papaverace family. Codeine and thebaine are important alkaloids of Papaver bracteatum which use widely due to its medicinal properties. Therefore it is necessary to determination the contents of these alkaloids in different parts of Iran. In order to determine the best natural habitat of Papaver bracteatum, containing the highest concentration of thebaine and codein different sample collected from different parts of Iran. Experimental: Using high performance liquid chromatography (HPLC) standard curve with the presence of two major alkaloids (thebaine and codeine) were drawn and alkaloids were extracted from capsule Papaver bracteatum and were determined by HPLC. Results & Discussion: Codeine contents in the sample of dry capsule Zanjan, Plour, Chalus road, Siah Bisheh, and Mazandaran were determined 0.04, 0.04, 0.03, 0.01 and 0.02% respectively. Thebaine content was determined 3.3, 0.61, 0.34, 0.31 and 0.06% respectively. Amounts of codeine for different regions ranged between 0.001 to 0.004% and, 0.06 to 3.3% for thebaine. The accessions collected from Zanjan has highest percentage of codeine and thebaine (3.34%) Industrial/Practical recommendation: The capsules collected from region of Zanjan in Iran have more contents of thebaine and codeine which possess many pharmaceutical applications, therefore it is highly recommended using accessions from the region of Zanjan to extract thebaine and codeine consumed in the pharmaceutical industry.
Authors and Affiliations
Zohreh Kadkhoda; Sajjad Sedaghat; Shams Ali Rezazadeh; Hasan Ali Naghdi Badi; Rahim Taghizad Farid; Farhad Harriri
Keywords
Related Articles
- EP ID EP23341
- DOI -
- Views 445
- Downloads 25
The phytochemical response of Melissa officinalis L to foliar application of hydro-alcoholic solutions (methanol and ethanol)
Introduction & Aim: The aim of this study was evaluating effect of methanol and ethanol foliar application as a new and safe technology in plant production on lemon balm’s (Melissa officinalis L.) volatile oil components...
Variation in yield and yield components in cultivated accessions of Satureja macrantha in Yazd
Background & Aim: The genus Satureja belonging to the family of lamiaceae and consists of over 235 different species throughout the world. Fourteen species grow naturally in IRAN of which eleven species are endemic. Diff...
A review on botany and ethnobotany of NepetabracteataBenth. grown in KhorasanRazavi province
Background & Aim: Nepetabracteata Benth is a medicinal plant belongs to the Lamiaceae family which wildly grows in Khorasan province. This herb is used by the indigenous people as afolkloric medicine in Khorasan. This pa...
بررسی اثر خشک کردن بر استخراج اینولین از کاسنی ریشه ای (Cichuriumintybus L.)
مقدمه و هدف: اینولین یک پلی ساکارید ذخیره ای از دسته فروکتون ها با خواص تغذیه‌ای و تکنولوژیکی منحصر بفردی است و ریشه کاسنی ریشه‌ای (چیکوری) حاوی اینولین با زنجیرهای بلند و پایدار بعنوان تنها منبع ریشه ای برای تولید صنعتی...
The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse
Background & Aim: The use of anti-nociceptive and anti-inflammatory drugs in clinical medicine is necessary and unavoidable. Since the use of synthetic drugs is associated with numerous side effects, the application of c...