DETERMINATION OF ANTIOXIDANT ACTIVITY OF CROCUS SATIVUS IN ADJUVANT INDUCED ARTHRITIC MICE
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 5
Abstract
Rheumatoid arthritis (RA) is a chronic systemic disease which results in pain, swelling, and stiffness in joints. It affects about 1% of the total world’s population. RA begins with an edematous thickening of the synovia which latter converts into inflammatory synovium called pannus which erodes the surrounding cartilage. Conventional therapy exists to overcome illness but prolonged uses of drugs cause various side effects. Several reports demonstrate herbal remedy for RA treatment. Saffron is the natural yellow spice derived from the flower of Crocus sativus, possess antioxidant, anti-inflammatory activities. Therefore, in this study role of saffron for its treatment has been explored in AIA mice. The effect of three doses of ethanolic extracts of Crocus sativus (Family: Iridaceae) on adjuvant-induced arthritic mice was examined and evaluated. FCA injection caused a significant increase in joint inflammation. A daily oral dose of Crocus sativus extract (CSE) for 47 days resulted in a significant decrease in Lipid peroxides level as compared to AIA mice, while on the other hand the significant increase in Catalase and Glutathione peroxidase activity was recorded. From the present study, it may be concluded that CSE is effective in scavenging the free radical and hence capable of reducing oxidative stress during disease.
Authors and Affiliations
K. Jaggi et al.
Keywords
Related Articles
- EP ID EP554785
- DOI -
- Views 74
- Downloads 0
PROTECTION OF HIPPOCAMPAL AND ISLET BETA CELLS IN VITRO BY EMODIN FROM LEAVES OF RUMEX CONFERTUS
The natural anthracene derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known as an anticancer agent. In the present work it was isolated for the first time from the ethanol extract of Rumex confertus leaves...
COMPOSITIONS, DISTRIBUTIONS AND STATUS OF ECONOMIC PLANTS AMONG INVASIVE FLORAS OF UTTARPARA, WEST BENGAL, INDIA
A survey was carried out from 2005 to 2010 to invent the invasive alien plant species and their economic uses in urban and adjoining rural areas of Uttarpara, Hooghly district, West Bengal. The study revealed the occurre...
A PRELIMINARY PHARMACOGNOSTICAL REPORT ON THE LEAF OF DREGEA VOLUBILIS (L.F.) BENTH. EX HOOK. F.
Dregea volubilis (L.f.) Benth. Ex Hook. f. is a large twinning shrub belonging to the family Asclepiadaceae. The leaf is amphistomatic with tetracytic, anomocytic, paracytic stomata. The sides of leaf in surface are stra...
EVALUATION OF ANTI-DIABETIC ACTIVITY ON n-BUTANOL FRACTION OF LEAF METHANOLIC EXTRACT OF CURCULIGO ORCHIOIDES (AMARYLLIDACAE) IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The aim of present study to evaluate anti-diabetic activity of methanolic extract n-butanol fraction of Curculigo orchioides (Amaryllidacae) against in streptozotocin induced diabetic rats. Fractions were administrated o...
IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF APOROSA LINDLEYANA BAILL.
The free radical scavenging activity of ethanolic root extract of Aporosa lindleyana (EREAL) was evaluated in vitro with the spectrophotometric method based on the inhibition of hydroxyl radical, the reduction of stable...