DETERMINATION OF ANTIOXIDANT ACTIVITY OF CROCUS SATIVUS IN ADJUVANT INDUCED ARTHRITIC MICE
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 5
Abstract
Rheumatoid arthritis (RA) is a chronic systemic disease which results in pain, swelling, and stiffness in joints. It affects about 1% of the total world’s population. RA begins with an edematous thickening of the synovia which latter converts into inflammatory synovium called pannus which erodes the surrounding cartilage. Conventional therapy exists to overcome illness but prolonged uses of drugs cause various side effects. Several reports demonstrate herbal remedy for RA treatment. Saffron is the natural yellow spice derived from the flower of Crocus sativus, possess antioxidant, anti-inflammatory activities. Therefore, in this study role of saffron for its treatment has been explored in AIA mice. The effect of three doses of ethanolic extracts of Crocus sativus (Family: Iridaceae) on adjuvant-induced arthritic mice was examined and evaluated. FCA injection caused a significant increase in joint inflammation. A daily oral dose of Crocus sativus extract (CSE) for 47 days resulted in a significant decrease in Lipid peroxides level as compared to AIA mice, while on the other hand the significant increase in Catalase and Glutathione peroxidase activity was recorded. From the present study, it may be concluded that CSE is effective in scavenging the free radical and hence capable of reducing oxidative stress during disease.
Authors and Affiliations
K. Jaggi et al.
Keywords
Related Articles
- EP ID EP554785
- DOI -
- Views 60
- Downloads 0
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF KANDANGKATHIRI KIRUTHAM IN ANIMAL MODEL
Kandangkathiri Kirutham (ghee of Solanum xanthocarpum) is a Siddha herbal formulation mentioned in Siddha textbook for the treatment of Ullnaakku Azharchi (Tonsillitis). It contains leaf juice of Kandangkathiri (Solanum...
IN-VITRO ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF LEAF EXTRACT OF VERBENA OFFICINALIS
The leaf of Verbena officinalis was collected, air dried under the shed, powdered, soaked in and extracted with 80% methanol. The crude extract was tested for it's in-vitro antibacterial activity against S. aureus and E....
A COMPREHENSIVE REVIEW ON PLANT EXTRACT AS AN HERBAL INDICATOR IN TRITREMETRIC ANALYSIS
The synthetic indicators are used in acid base titration for determination of end point. A part of its application, the synthetic indicators has several limitations such toxic in nature, costly, corrosive and etc. Thus,...
AQER QERHA (ANACYCLUS PYRETHRUM DC.) A NOBEL DRUG OF UNANI SYSTEM OF MEDICINE-A REVIEW
Aqer Qerha (Anacyclus pyrethrum DC.), family Asteraceae is a perennial, procumbent herb, native to North Africa and Arab countries and in India, it is found in the Himalayas, Jammu and Kashmir, and North India. In Unani...
HULBAH (TRIGONELLA FOENUM-GRAECUM.): A REVIEW
The Hulbah, Trigonella foenum-graecum of family Legumenasea which is commonly known as methi, in the traditional system of medicine including Unani Medicine. Hulba is an annual herb, 1-2 fit long contains the seed in lon...