DETERMINATION OF THE ACUTE TOXICITY PARAMETERS OF BIOLOGICALLY ACTIVE ADDITIVE «SIVOSELEN PLUS»
Journal Title: Прогресивні техніка та технології харчових виробництв ресторанного господарства і торгівлі - Year 2015, Vol 1, Issue
Abstract
The influence of dietary supplement «Sivoselen Plus» on the organism of linear white rats is investigated. The acute toxicity parameters of the additive (the effective and mortality dose rates, its security degree) are calculated using the Probit Analysis computer program. The solution of dietary supplement «Sivoselen Plus» was entered once a day at the amount of 0.7 to 6 ml per rat (it is the maximum allowable dose in terms of oral) that in equivalent to dose is from 4375 to 37500 mg/kg appropriately. The LD50 indicator of biologically active additive at introduction into the white rats’ stomachs is 425.4636 mg/kg, the calculated value of LD16 is 122.9786 mg/kg, LD84 is 1471.9574 mg/kg and the LD99 is 7759.4101 mg/kg in recalculation on Selenium. Based on the data of the maximum available dose of biologically active additive «Sivoselen Plus» the graph, expressing the «dose-effect» dependence, is built. The additive toxicity class is 5th that testifies to its relative non-toxicity. The ability to create organic selenium-containing compounds based on the milk whey and calcium selenate is proved in practice. The technique of additive dispensing is developed
Authors and Affiliations
Микола Головко, Владислав Применко, Тетяна Головко
Keywords
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