Determination of the ionization constants of salts, derivatives 2-(4-R-5-(thiophen-2-yl)-1,2,4-triazole-3-ylthio)acetate acids
Journal Title: Фармацевтичний журнал - Year 2014, Vol 1, Issue 1
Abstract
Indicators of ionization constants are very important material from both the theoretical and practical view. The ionization constants from the chemical point of view can show the acidity or basicity of compounds, and from a biological point of view, helping to orient in which part of the gastrointestinal tract will occur an absorption of a substance, in the case of oral application. The aim of research was to conduct the theoretical calculation and experimental determination of the ionization constants of salts, derivatives 2-(4-R 5-(thiophen-2-yl)-1,2,4-triazol-3-ylthio)acetate acid with the followed establishment of connection for such material. Calculations of the compounds ionization constants were conducted by Spykman and Bates methods. Experimental determination of the ionization constants of salts, derivatives 2-(4-R-5-(thiophen-2-yl)-1,2,4-triazol-3-ylthio)acetate acid was conducted by the potentiometric titration method of the samples in aqueous solution. The equivalence point was determined by using an ionomer EW -74, using a glass (ECL 6307) and silver chloride (EVL 1193) electrodes. As a result of research was established, that facts, received by theoretical calculations method, correlated with the experimental, the presence and nature of substituents at the N4 atom of 1,2,4-triazole nucleus affect at the compounds acidity and basicity, and also is made a hypothesis, that discussed acids and their salts at the oral application will absorbed more actively in duodenum or colon.
Authors and Affiliations
V. A. Salionov, A. I. Avramenko, A. G. Kaplaushenko, O. I. Panasenko, Ye. G. Knysh
Keywords
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