Determining Inducible Clindamycin Resistance in Staphylococcus Aureus from Various Clinical Samples by D-Zone test with Special Reference with MRSA
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Clindamycin is used in the treatment of skin and soft tissue infections caused by staphylococcus aureus and also alternative for patients who are allergic to penicillin. Treatment of an infection caused by as strain carring inducible erm gene using clindamycin or any non inducer macrolide can lead to clinical failture. Thus making the need of detecting such resistance by a Disc test (D- Test). Material & Methods: D- test was test to detect inducible clindymycin resistance with standard erythromycin and clindamycin disc. Of the 147 S. aureus isolates, 95 were methicillin resistant staphylococcus aureus. 45.26% of these were inducible clindamycin resistant. There were 52 methicillin sensitive staphylococcus aureus isolates, only 11.53% of which were inducible clindamycin resistant. Conclusion: Performing D test regularly, the diagnostic laboratory can properly guide clinician regarding judicious use of clindamycin in skin and soft tissue infection. thus Clindamycin could be a valuable weapon against staphylococcus infection.
Authors and Affiliations
Sachin Mishra
Keywords
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