DEVELOPMENT AND EVALUATION OF MULTILAYERED LAYERED MATRIX TABLETS OF WATER SOLUBLE DRUG
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 4
Abstract
A new approach to zero- order drug delivery that includes geometric factors is described. Systems such as multilayered tablets and other geometrically altered devices have been created to perform this function. The multi-layered matrix system overcomes inherent disadvantages of non-linearity associated with diffusion controlled matrix devices by providing additional release surface with time to compensate for the decreasing release rate. These formulations designed to deliver the drug at predetermined rate, maintain therapeutically effective concentrations in systemic circulation for prolonged period of time. Recently, pharmaceutical research has focused on controlled drug delivery offer definite advantages over conventional release formulation of the same drug. Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity. In the present study, guar gum was used as hydrophilic matrix carrier for designing oral controlled drug delivery systems of highly soluble drug lamivudine. Three layered matrix tablets of lamivudine prepared by wet granulation technique were subjected for various evaluating parameters and optimized.
Authors and Affiliations
Ravi Shekhar, P. Sharma
Keywords
Related Articles
- EP ID EP618419
- DOI 10.25004/IJPSDR.2018.100406
- Views 101
- Downloads 0
USE OF NANOTECHNOLOGY IN THE DIAGNOSIS, PREVENTION AND THERAPY OF CANCER
Nanotechnology, along with other fields such as theranostics, genomics or proteomics, has one of the most potential uses in prevention, diagnosis and treatment of diseases. Formulation of different nanoparticles and modi...
Formulation and Characterization of Ondansetron Hydrochloride Matrix Tablets for Sustained Drug Delivery
The objective of proposed work was to develop Ondansetron Hydrochloride (OND HCl) sustained release matrix tablets for the better treatment of vomiting for extended period of time. Sustained release matrix tablet is the...
SYNERGISTIC ANTIHYPERLIPIDEMIC ACTIVITY OF SALACIA OBLONGA, SALACIA ROXBHURGII AND LAGERSTROEMIA PARVIFLORA
The present study aimed that evaluation antihyperlipidemic activity of Salacia oblonga, Salacia roxbhurgii and Lagerstroemia parviflora individually and combined plants extracted poly herbal extraction and screened for p...
ANTI-HEPATOTOXIC PROPERTY OF ROOTS AND LEAVES OF CHASSALIA CURVIFLORA (WALL.) THWAITES AGAINST CCL4 INDUCED LIVER DAMAGE IN RATS
In the present study the roots and leaf ethanolic extracts of Chassalia curviflora were screened for their anti hepatotoxic and anti oxidant effects in experimentally induced liver injury by carbon tetra chloride. Liver...
COGNITIVE ENHANCING, ANTI ACETYLCHOLINESTERASE AND ANTIOXIDANT PROPERTIES OF TAGETES ERECTA AGAINST DIAZEPAM INDUCED AMNESIA IN RODENTS
Oxidative stress can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to ev...