Formulation and Characterization of Ondansetron Hydrochloride Matrix Tablets for Sustained Drug Delivery

Abstract

The objective of proposed work was to develop Ondansetron Hydrochloride (OND HCl) sustained release matrix tablets for the better treatment of vomiting for extended period of time. Sustained release matrix tablet is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The matrix tablets of OND HCl were prepared by direct compression method using varying ratio of hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose. The bends of tablets were evaluated for bulk and tapped density, % compressibility index and angle of repose and powder of all formulations blend exhibited that low interparticle friction and excellent flow characteristics. The prepared matrix tablets were then assessed for different physical tests like consistency of weight, thickness, hardness, friability, drug content and in vitro drug release. Each batch of the OND HCl matrix tablets were of good quality as to hardness, thickness, friability and % medicament content. The in vitro drug release study was done for 2 hours by utilizing paddle technique in 0.1N HCl (pH 1.2) as dissolution media and 6 hours using phosphate buffer (pH 6.8) as dissolution media. The drug release study showed that all formulation FMT-1, FMT-2, FMT-3, FMT-4, FMT-5 and FMT-6 were provide the drug release on sustained manner up to 8 hrs. Amongst the developed matrix tablets formulations, FMT-2 containing ethyl cellulose (100 mg) was optimized as best because FMT-2 show highest drug release profile and promoting the sustained release of drug, which could potentially improve the patient compliance.

Authors and Affiliations

P Gupta, V A Sethi, A W Siddiqui, L K Tyagi

Keywords

Related Articles

EFFECT OF BOUGAINVILLEA SPECTABILIS LEAVES ON SERUM LIPIDS IN ALBINO RATS FED WITH HIGH FAT DIET

Dyslipidemia is major problem among population those have sedentary life style as well as in diabetics. Bougainvillea spectabilis is most commonly found in India as an ornamental plant and has got anti-diabetic action du...

DESIGN DEVELOPMENT AND EVALUATION OF NANOSUSPENSION OF AZITHROMYCIN

The objective of this study is to prepare a formulation of Azithromycin which increase the oral bioavailability as well as increased solubility and dissolution rate. In the present study nine formulations were formulated...

ANTIOXIDANT ACTIVITIES OF INCLUSION COMPLEXES OF 2-(BENZOTHIAZOLYL-2’) HYDRAZONO-3-PHENYL 5-ARYLIDENE- 4- THIAZOLIDINONE DERIVATIVES WITH Β-CYCLODEXTRIN

The present study focused on the preparation and antioxidant studies of inclusion complexes of some compounds of 4-Thiazolidinone derivatives with β-cyclodextrin. The inclusion complex has been prepared in order to incre...

THE NEWLY DEVELOPED HIGHLY SENSITIVE METHOD FOR THE DETERMINATION OF CAPECITABINE BY USING UV-SPECTROSCOPY

Capecitabine is a fluoropyrimidine carbamate, designed as 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) meant to be administered orally. Capecitabine is used as first line monotherapy for metastatic colorectal...

FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF GLIBENCLAMIDE

Matrix type transdermal patches containing Glibenclamide were prepared using three different polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was...

Download PDF file
  • EP ID EP664870
  • DOI 10.25004/IJPSDR.2019.110408
  • Views 130
  • Downloads 0

How To Cite

P Gupta, V A Sethi, A W Siddiqui, L K Tyagi (2019). Formulation and Characterization of Ondansetron Hydrochloride Matrix Tablets for Sustained Drug Delivery. International Journal of Pharmaceutical Sciences and Drug Research, 11(4), 147-151. https://europub.co.uk/articles/-A-664870