Formulation and Characterization of Ondansetron Hydrochloride Matrix Tablets for Sustained Drug Delivery
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2019, Vol 11, Issue 4
Abstract
The objective of proposed work was to develop Ondansetron Hydrochloride (OND HCl) sustained release matrix tablets for the better treatment of vomiting for extended period of time. Sustained release matrix tablet is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The matrix tablets of OND HCl were prepared by direct compression method using varying ratio of hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose. The bends of tablets were evaluated for bulk and tapped density, % compressibility index and angle of repose and powder of all formulations blend exhibited that low interparticle friction and excellent flow characteristics. The prepared matrix tablets were then assessed for different physical tests like consistency of weight, thickness, hardness, friability, drug content and in vitro drug release. Each batch of the OND HCl matrix tablets were of good quality as to hardness, thickness, friability and % medicament content. The in vitro drug release study was done for 2 hours by utilizing paddle technique in 0.1N HCl (pH 1.2) as dissolution media and 6 hours using phosphate buffer (pH 6.8) as dissolution media. The drug release study showed that all formulation FMT-1, FMT-2, FMT-3, FMT-4, FMT-5 and FMT-6 were provide the drug release on sustained manner up to 8 hrs. Amongst the developed matrix tablets formulations, FMT-2 containing ethyl cellulose (100 mg) was optimized as best because FMT-2 show highest drug release profile and promoting the sustained release of drug, which could potentially improve the patient compliance.
Authors and Affiliations
P Gupta, V A Sethi, A W Siddiqui, L K Tyagi
Keywords
Related Articles
- EP ID EP664870
- DOI 10.25004/IJPSDR.2019.110408
- Views 125
- Downloads 0
A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF TRIFLUOPERAZINE AND ISOPROPAMIDE IN TABLET DOSAGE FORM
The present paper describes a reverse phase HPLC method for simultaneous estimation of Trifluoperazine and Isopropamide from their combined tablet dosage form. The proposed RP-HPLC method utilizes an Agilent Zorbax, C18...
DEVELOPMENT AND EVALUATION OF MULTILAYERED LAYERED MATRIX TABLETS OF WATER SOLUBLE DRUG
A new approach to zero- order drug delivery that includes geometric factors is described. Systems such as multilayered tablets and other geometrically altered devices have been created to perform this function. The multi...
METHOD DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN IN API BY RP-HPLC AND UV-SPECTROSCOPY
In the present study, two analytical methods were developed for the estimation of Dapagliflozin in API. Method A: RP-HPLC method, Method B: UV spectroscopic method. In method A, the drug showed linearity in the range of...
HEPATO PROTECTIVE EFFICACY OF TERMINALIA CHEBULA, TERMINALIA BELLIRICA, PHYLLANTHUS EMBLICA AND THEIR FORMULATION ON IMIDACLOPRID INDUCED LIVER TOXICITY BY HISTOPATHOLOGICAL AND BIOCHEMICAL PARAMETERS
Terminalia chebula, Terminalia bellirica, Phyllanthus emblica and their formulations are used as a phytotherapeutic medicine for hepatic diseases. In the present study the effect of methanolic extract of herbal powder wa...
ISOLATION AND CHARACTERIZATION OF MUCILAGE FROM CINNAMON VERUM
From the last few decades the importance of search for natural polymer as pharmaceutical excipients has been increasing due to their various advantages. Natural polymer has been used in different pharmaceutical formulati...