Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 4
Abstract
Pulsatile release profile is characterized by a lag time followed by rapid and complete drug release. Pulsatile drug delivery systems are classified into time-controlled and site-specific delivery systems. The lag time is taken as the time of less than 10% drug release. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps i.e. firstly core tablet was prepared containing Nifidipine; secondly core tablet was coated with polymer blend of ethyl cellulose (water insoluble polymer) and Eudragit L 100 (Enteric polymer). From the study it was concluded that the formulation having a coating level of 50% w/w of core and weight ratio of ethyl cellulose to Eudragit L 100 (20%) showed lesser release profile as compared to other formulation i.e. 52.83% in 12hrs. As we increase the weight ratio of ethyl cellulose to Eudragit L 100 better entrapment of drug leading to controlled release of drug.
Authors and Affiliations
Renu Dinkar| Department of Pharmacy,GIS Institute of Professional Studies, Dehradun. (Uttarakhand), India, Govind Mohan| Department of Pharmacy,NIMS University, Jaipur. (Rajasthan), India, Kumud Upadhyaya| Department of Pharmaceutical Sciences, Kumaun Univesity, Nainital. (Uttarakhand), India
Knowledge, attitude, and perception of HIV / AIDS among married women
Background: In India, the rising prevalence of HIV among pregnant women is of great concern. Pregnant women are much receptive on health matters. So, it is important to assess their knowledge, attitude and perception r...
Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system
Objective: To deal with the formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet containing Carica papaya, Vitex negundo, Moringa oleifera and Boswellia serrata used a...
Immunoformatics and Molecular Simulation Study Unfold the Immunological Repertoire of Sabia Virus Glycoprotein G1
Sabia virus Glycoprotein G1 (GP1) is a peripheral membrane protein involved in viral adsorption and consequential pathogenic infection. Glycoprotein G1 (GP1) was subjected to immunoformatic and molecular simulation stu...
Formulation development and characterization of fast dissolving tablets of oxcarbazepine
The objective of this study was formulation development and evaluation of Oxcarbazepine Fast Dissolving Tablets (FDTs) prepared by sublimation technique where different sublimating agents like camphor and menthol were...
Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be...