DEVELOPMENT AND IN VITRO EVALUATION OF MOUTH DISSOLVING FILMS OF CAPTOPRIL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 11
Abstract
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme(ACE), the enzyme responsible for the conversion of angiotensin I (AT I) to angiotensinII (AT II). Captoprilmaybeusedinthetreatmentofhypertension.Thus formulating Captopril into a fast dissolving dosage form would provide fast relief. The bitter taste of Captopril was masked with β-cyclodextrin. Inclusion complexes ofdrug β-cyclodextrin were prepared by kneading method in 1:1 molar ratios. The preparedinclusion complexes were characterized by FTIR spectroscopy suggesting no interaction. The oralfast dissolving films were prepared by using different polymers like HPMC, PVA, PVPand carbopol 934P with super disintegrants like micro crystalline cellulose(MCC) and croscarmellose sodium (CCS). Theprepared films evaluated for folding endurance, swelling index, surface pH, in-vitrodisintegration time, drug content, FTIR study, and in-vitrodrug release.The physical appearance and folding endurance properties were found to be good with the films having clear, colorless and smooth surface without any scratches. The average folding endurance time was found within the range of123 to 196 times.The drugcontent was found in the range of 92.21%to98.97%. The in-vitrodisintegration time was found to be in the range of 15 to48sec and the surface pH of the all formulations was in the range of 6.02 to 6.79. The in-vitrodrug releaseshowed83.49to96.79%drugreleasewithin10minutes. The formulations F4, F5, F8 showed the highest amount of drug release as these formulations were having croscarmellose sodiumas superdisintegrants.
Authors and Affiliations
ST Ali, Mohammed Jahangir, MD. Ahmed, Abdul Muheem, Mohammed Shahab, Durga Bhavani, MA Saleem
Keywords
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- EP ID EP106600
- DOI 10.7897/2230-8407.0611148
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