DEVELOPMENT AND IN VITRO EVALUATION OF MOUTH DISSOLVING FILMS OF CAPTOPRIL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 11
Abstract
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme(ACE), the enzyme responsible for the conversion of angiotensin I (AT I) to angiotensinII (AT II). Captoprilmaybeusedinthetreatmentofhypertension.Thus formulating Captopril into a fast dissolving dosage form would provide fast relief. The bitter taste of Captopril was masked with β-cyclodextrin. Inclusion complexes ofdrug β-cyclodextrin were prepared by kneading method in 1:1 molar ratios. The preparedinclusion complexes were characterized by FTIR spectroscopy suggesting no interaction. The oralfast dissolving films were prepared by using different polymers like HPMC, PVA, PVPand carbopol 934P with super disintegrants like micro crystalline cellulose(MCC) and croscarmellose sodium (CCS). Theprepared films evaluated for folding endurance, swelling index, surface pH, in-vitrodisintegration time, drug content, FTIR study, and in-vitrodrug release.The physical appearance and folding endurance properties were found to be good with the films having clear, colorless and smooth surface without any scratches. The average folding endurance time was found within the range of123 to 196 times.The drugcontent was found in the range of 92.21%to98.97%. The in-vitrodisintegration time was found to be in the range of 15 to48sec and the surface pH of the all formulations was in the range of 6.02 to 6.79. The in-vitrodrug releaseshowed83.49to96.79%drugreleasewithin10minutes. The formulations F4, F5, F8 showed the highest amount of drug release as these formulations were having croscarmellose sodiumas superdisintegrants.
Authors and Affiliations
ST Ali, Mohammed Jahangir, MD. Ahmed, Abdul Muheem, Mohammed Shahab, Durga Bhavani, MA Saleem
Keywords
Related Articles
- EP ID EP106600
- DOI 10.7897/2230-8407.0611148
- Views 114
- Downloads 0
FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF VENLAFAXINE HCl
The purpose of the present investigation is to formulate gastroretentive floating tablets of Venlafaxine hydrochloride thus increasing its gastric residence time as well as bioavailability and therapeutic efficacy. Venla...
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD IN THE DETECTION OF EFAVIRENZ IN BULK DRUG AND TABLET FORMULATION
A simple, highly sensitive, isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed for the determination of efavirenz in the bulk drug and tablet dosage forms. Elution medium consisting o...
EFFECT OF SHORT TERM EXPOSURE OF BUTYLPARABEN ON UTERINE WEIGHT OF OVARIECTOMISED C3H ALBINO MICE
Butylparaben is a commonly used anti microbial preservative in cosmetics, pharmaceuticals and food. The high rate of human exposure of butylparaben has been of growing concern as it is found to mimic estrogen activity in...
OBSERVATIONAL STUDY OF ROLE OF LEKHANA BASTI AND VIRECHANA KARMA IN STHAULYA (OBESITY)
Sthaulya (Obesity) is occurs as a result of lack of physical activity with increased intake of food. The industrialization, stress during the work. Dietary habits, lack of exercise and various varieties among the daily d...
SYNTHESIS AND SCREENING OF SOME DIHYDROPYRIMIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS
The wide applications of pyrimidine fused heterocyclic compounds prompted us to synthesize a new series of dihydropyrimidine derivatives through Biginelli reaction. The synthesized compounds were characterized by IR and...