Development and in vitro- in vivo evaluation of Nitazoxanide sustained release tablets
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 2
Abstract
Objective: The objective of the present investigation was to develop a sustained release (SR) tablet formulation of Nitazoxanide. Methods: Nitazoxanide Tablets were prepared by employing wet granulation methods and hydrophilic polymers used as drug release retardants. The dissolution data also evaluated for the drug release mechanism and kinetics. The optimized formulation was subjected for in vivo studies in rabbits. Results: Based on data obtained from the in vitro drug release studies 5%w/w of Methocel K100M was selected as a release retardant. The drug release followed first order kinetics and fickian diffusion. Conclusion: Present investigation indicates that the developed formulation was able to sustain the drug release.
Authors and Affiliations
Lakshminarayana Reddy Golamaru, K. Rajnarayana, K. N. Jayaveera
Keywords
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- EP ID EP435263
- DOI 10.7439/ijpr.v6i2.3017
- Views 58
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