DEVELOPMENT AND INVITRO CHARACTERIZATION OF PACLITAXEL SUSTAINED RELEASE MICROSPHERS
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 4
Abstract
The objective of the present work was to formulate and evaluate sustained release paclitaxel microspheres for treating breast, ovarian and colon cancer effectively. Sustained release paclitaxel microspheres for minimum five days depot which had been designed based on disease condition were prepared in the form of microspheres for subcutaneous administration for sustained release. Different formulations were prepared by using Solvent Evaporation technique and ionic gelation method using synthetic polymer like HPMC K 100, Eudragit RS 100, and Ethyl cellulose. The formulations were evaluated for percentage yield, entrapment efficiency, particle size analysis, and In-vitro drug release. The optimized formulation of the microspheres containing polymer and drug was found to be compatible from FTIR studies. The In-vitro release of drug from the formulations were studied in pH 7.4 phosphate buffer solution, and it was found that the prepared microspheres (F10) were able to sustained the release of the drug 48 hrs of about 42.28%. The release of the drug from the microspheres was found to follow zero order kinetics
Authors and Affiliations
S. Santhosh Kumar , V. Naga Manoj Kiran
Keywords
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