DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING ORAL FILM CONTAINING ARIPIPRAZOLE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2017, Vol 9, Issue 6
Abstract
The present investigation was aimed with the objective of developing fast dissolving oral films of Aripiprazole to attain quick onset of action for the better management of Schizophrenia. Fourteen formulations (F1-F14) of Aripiprazole mouth dissolving films by solvent-casting method using HPMC E5, HPMC E15, Maltodextrin, PG and PVA. Formulations were evaluated for their physical characteristics, thickness, folding endurance, tensile strength, disintegration time, drug content uniformity and drug release characteristics and found to be within the limits. Among the prepared formulations F13 showed minimum disintegration time 10 sec, maximum drug was released i.e. 99.49 ± 0.36% of drug within 8 min when compared to the other formulations and finalized as optimized formulation. FTIR data revealed that no interactions take place between the drug and polymers used in the optimized formulation. The in vitro dissolution profiles of marketed product and optimized formulation was compared and found to be the drug released was 20.73 ± 0.25 after 8 min. Therefore, it can be a good alternative to conventional Aripiprazole for immediate action. In vitro evaluation of the Aripiprazole fast dissolving oral films confirmed their potential as an innovative dosage form to improve delivery and quick onset of action of Aripiprazole. The mouth dissolving film is potentially useful for the treatment of Schizophrenia where the quick onset of action is desired.
Authors and Affiliations
S. Jyothi Sri, D. V. R. N Bhikshapathi
Keywords
Related Articles
- EP ID EP618328
- DOI 10.25004/IJPSDR.2017.090607
- Views 91
- Downloads 0
OPTIMIZATION OF EXTRACTION CONDITIONS AND DEVELOPMENT OF A SENSITIVE HPTLC METHOD FOR ESTIMATION OF WEDELOLACTONE IN DIFFERENT EXTRACTS OF ECLIPTA ALBA
Eclipta alba has been used in Ayurvedic medicine for treatment of various ailments. An attempt has been made to optimize different extraction conditions for Eclipta alba. Further an accurate, precise, reproducible and se...
ESTIMATION OF ELETRIPTAN HYDROBROMIDE IN ORAL FILM DOSAGE FORM BY RP-HPLC
A simple, precise, rapid and accurate RP-HPLC method was developed for the percentage drug release estimation of Eletriptan Hydrobromide in oral film dosage form. Eletriptan Hydrobromide is used to treat severe migraine...
FABRICATION AND CHARACTERIZATION OF CEFOPODOXIME PROXETIL SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT
Cefopodoxime Proxetil belongs to BCS class IV and used in treatment of upper respiratory tract and urinary tract infections. Solid dispersions (SDs) are one of the most promising strategies to improve the solubility, dis...
DEVELOPMENT AND IN VIVO EVALUATION OF NELFINAVIR EXTENDED RELEASE TRILAYER MATRIX TABLETS IN THE MANAGEMENT OF AIDS
The purpose of this investigation was to design and develop trilayer matrix tablets of Nelfinavir prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropyl methylce...
ANTI-INFLAMMATORY EFFECTS AND SAFETY OF EXTRACTS AND ESSENTIAL OIL FROM CLINOPODIUM GILLIESII (MUÑA MUÑA)
The chemical machinery of vegetables offers a great diversity of biological properties and plays a fundamental role in the field of pharmacology. The search for new drugs with fewer adverse effects represents a challenge...