DEVELOPMENT AND OPTIMIZATION OF FIXED DOSE ANTIHYPERTENSIVE COMBINATION DRUGS USING DOUBLE LAYER SUSTAINED RELEASE MICROSPHERE TECHNOLOGY
Journal Title: International Journal of Pharmaceutical and Biological Research - Year 2010, Vol 1, Issue 5
Abstract
For the development of Double walled microspheres, we have selected polymer: Chitosan and Eudragit E100. The inner core which is made up of polymer chitosan will contain drug; propranolol hydrochloride and outer shell which is made up of polymer Eudragit E100 contain; frusemide.Since Eudragit E100 is dissolving below pH5, will release the drug (furosemide) and attain therapeutic plasma concentration, which reduces the body fluid thus also reduces blood pressure then the inner core chitosan’s is a mucoadhesive, contains propranolol hydrochloride, adhesive to mucous layer of Stomach or GIT will provide the sustain release of the drug for a longer period (24 hr).Therefore, it was the goal of present study to adapt methods of double-walled fabrication with modifications, for the successful encapsulation of water-soluble. Propanolol hydrochloride and water insoluble Furosemide, resulting in reduced-initial bursts as well as sustained release profiles suitable for the treatment of hypertension.
Authors and Affiliations
Mukesh kumar Sahu , Dabeer Ahmad
Keywords
Related Articles
- EP ID EP113662
- DOI -
- Views 160
- Downloads 0
METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDY FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND INDAPAMIDE BY REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN PURE AND MARKETED FORMULATION.
An approach of forced degradation study was successfully applied for the development of a stability-indicating assay method for simultaneous determination of telmisartan and indapamide in a formulation in the presence of...
Evaluation of the Toxic Effects of Clozapine in Zebra fish (Danio rerio) embryos with the Fish Embryo Toxicity Test
Clozapine (an atypical antipsychotic drug) is indicated in treatment-refractory schizophrenia. Antipsychotics have been reported to have cardiotoxic effects in humans.The zebra fish (Danio rerio) is a tropical cyprinid u...
Antimicrobial effect of Callus and Natural plant extracts of Premna serratifolia L
Premna serratifolia L. is an important medicinal shrub used in traditional system of medicines as cardio tonic, antibiotic, anti-coagulant, carminative, hepatoprotective, anti tumor etc. The present study aims in the eva...
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN TABLET DOSAGE FORM BY RP-HPLC
A simple reverse phase liquid chromatographic method has been developed and subsequently validated for simultaneous determination of Ofloxacin and Ornidazole in combination. The separation was carried out using a m...
PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE DIFFERENT EXTRACTS OF TUBER OF AMORPHAPHALLUS PAEONIIFOLIUS (ARACEAE)
The present study was aimed to investigate phytochemicals present in the tuber extract of Amorphaphallus paeoniifolius and development of new solvent system for thin layer chromatography of petroleum ether and ethanol ex...