Development and validation of a RP- HPLC method for the quantittation studies of metronidazole and furazolidone from product Enteroguard M
Journal Title: Medicamentul Veterinar / Veterinary Drug - Year 2010, Vol 4, Issue 2
Abstract
An isocratic high-performance liquid chromatography (HPLC) procedure was developed for quantitative determination of metronidazole and furazolidone in tablet dosage forms of ENTEROGUARD M. HPLC separation was carried out by reversed phase chromatography Kromasil C18 (250 mm x 4,6 mm i.d.; 5 +m particle size), held at 25°C. The mobile phase consisted of methanol/ 0,1% phosphoric acid aq.(20/ 80 v/ v), run at flow rate of 1 mL/min and with UV detection at 317 nm. Method validation investigated parameters such as linearity (r2 = 0. 9999), range, precision, accuracy and specificity. The described method can be successfully applied for the analysis of ENTEROGUARD M tablets.
Authors and Affiliations
Elena Oltean, B. Milea
Keywords
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