DEVELOPMENT AND VALIDATION OF AN RP- UFLC METHOD FOR THE ESTIMATION OF DEXCHLORPHENIRAMINE MALEATE
Journal Title: Hygeia:journal for drugs and medicines - Year 2017, Vol 9, Issue 2
Abstract
Plan: Dexchlorpheniramine maleate is a Chlorpheniramine dextrorotatory isomer, which is twice active than Chlorpheniramine. It’s widely used in the coughs, cold and allergic conditions including angioedema, urticaria, conjunctivitis, rhinitis, and pruritic skin disorders. The main objective of the present research work deals with the development of simple, rapid and sensitive RP- UFLC analytical method for estimation of Dexchlorpheniramine maleate in bulk and finished formulation. Methodology: simple, rapid and sensitive RP- UFLC analytical method was developed. Optimized chromatographic separation condition was done by using an isocratic mode with the mobile phase of 25 mM of potassium dihydrogen ortho phosphate (pH 4) and acetonitrile at the ratio of 80:20v/v with a flow rate of 1ml/min. Stationary phase used was C18 column (250 x 4.6 mm). Dexchlorpheniramine maleate detection was carried at 260 nm. The developed method was evaluated for the validation parameters as per the ICH guidelines. Outcome: The developed optimized chromatographic condition was achieved and results showed good peak resolution. The developed method for the Dexchlorpheniramine maleate can be used for the qualitative and quantitative estimation of finished and bulk formulations.
Authors and Affiliations
SHANMUGAM R, MURALI P, LALITHA PRIYANKA. D
Keywords
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- EP ID EP334139
- DOI 10.15254/H.J.D.Med.9.2018.171
- Views 48
- Downloads 0
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