DEVELOPMENT AND VALIDATION OF ASSAY METHOD FOR MELOXICAM TABLETS BY RP-HPLC
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
A simple, precise, accurate and economical RP-HPLC method has been developed and validated for the assay of Meloxicam tablets. The method was developed using pH 7.0 Phosphate buffer: Acetonitrile (40:60 v/v) in isocratic mode and Waters Xterra C 18 (150 X 4.6mm), 5µ column. Flow rate and detection wavelengths were fixed at 0.8 ml/min and 344 nm. Retention time for Meloxicam was found to be 2.448 minutes. Method was validated as per ICH guidelines to test its suitability for intended purpose. Linearity range for Meloxicam was set at 10-75 µg/ml with correlation coefficient 0.999. Accuracy values for method were found to be 99.53- 99.66%. Method found to be robust against changes in flow rate, organic composition, pH of mobile phase and detection wavelength. The proposed method is suitable for quality control analysis of Meloxicam tablets.
Authors and Affiliations
K. Ranjith, M. V. Basaveswara Rao, T. E. G. K. Murthy
Keywords
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- EP ID EP33125
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