Development and validation of inductively coupled plasma mass spectrometry method for simultaneous determination of tin (SN) levels in excipients and formulations
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2017, Vol 4, Issue 3
Abstract
The pharmaceutical dosage form manufacturing process use some of polymers, which contains traces of inorganic elements like Tin (Sn) content. The traces of inorganic elements were determined by using inductively coupled plasma mass spectroscopy (ICP-MS). It is a sensitive method used to determine the inorganic elements by atomic mass value. In the present study Tin (Sn) was extracted by the sample using microwave-assisted digestion with hydrochloric acid. Different validation parameters were employed to evaluate the method in terms of selectivity, specificity, method precision, accuracy, intermediate precision and standard measurement uncertainty. The mass value of tin element is 118 as per the Perkin Elmer instrument recommendations. The results indicate that this method could be used for the routine measurement of tin (Sn) in the pharmaceutical laboratories.
Authors and Affiliations
Jagadeswara Rao K, Murali Mohan SV, Rama Rao Malla
Keywords
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- EP ID EP310594
- DOI 10.18231/2394-2797.2017.0017
- Views 87
- Downloads 0
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