DEVELOPMENT AND VALIDATION OF METHOD FOR DETERMINATION OF CICLESONIDE IN (MICRONIZED) BY HPLC
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 7
Abstract
A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of Ciclesonide has been developed and validated. The separation was achieved from HPLC Column (Waters Symmetry C18 5 ยต; 4.6 mm x 250 mm) with a mobile phase consisting of 85 volume of Ethanol with 15 volume of Millie-Q-Water at a flow rate of 1.10 ml/min with UV detection at 242 nm. The method is specific and it is observed that no interference with diluents. The proposed method is accurate with 99.6 % recovery for Ciclesonide and precise (% RSD of area of system precision, % RSD of assay of method precision and Intermediate precision are found to be 0.20 %, 0.20 % and 0.20 % respectively). From the linearity study the correlation coefficient is found to be 0.9999, which indicates that the method is linear over 10 % to 150 % range. The method is found robust for possible changes. Therefore, this method can be used as a more convenient and efficient option for the analysis of Ciclesonide to establish the quality of the drug substance during routine analysis with consistent and reproducible results.
Authors and Affiliations
Momin Mohammad Motalib, Anisuzzaman Md. , Begum Ara, Bellah Faysal, Islam Mostaharul, Parimal Talukder
Keywords
Related Articles
- EP ID EP98739
- DOI 10.7897/2230-8407.04712
- Views 117
- Downloads 0
SUSTAINED RELEASE OF NIFEDIPINE FROM MATRIX TABLETS OF ITS SOLID DISPERSIONS EMPLOYING SUPERDISINTEGRANTS
The present work was planned with the objective of preparing nifedipine (N) solid dispersions in cross carmellose sodium(CCS) and sodium starch glycholate (SSG) and were investigated with a view to design sustained relea...
SUSTAINED RELEASE DEVICE CONTAINING ORNIDAZOLE FOR PERIODONTITIS
The purpose of this study was to develop a sustained release device containing ornidazole for insertion within periodontal pockets. Cast films of ethyl cellulose with dibutyl phthalate as plasticizer, containing ornidazo...
PHYTOCHEMICAL AND CLINICAL EVALUATION OF SARIBA (HEMIDESMUS INDICUS) ON WOUND HEALING
Present study was carried out to screen the phyto-chemical and clinical evaluation of wound healing property of Sariba (Hemidesmus indicus) root paste on chronic wounds. Physico-chemical analysis of Hemidesmus indicus li...
MENTAL HEALTH CHALLENGES AND POSSIBLE SOLUTIONS WITH SPECIAL REFERENCE TO ANXIETY
Mental disorders are universal and very common. No country can postpone service development until the finalization of national level epidemiological surveys. It should be noted also that such surveys are very costly and...
SIMULTANEOUS ESTIMATION OF AMOXICILLIN TRIHYDRATE AND BROMHEXINE HYDROCHLORIDE IN ORAL SOLID DOSAGE FORMS BY SPECTROPHOTOMETRIC METHOD
Two accurate, precise, rapid and economical methods were developed and validated for the estimation of Amoxicillin Trihydrate and Bromhexine Hydrochloride in Bulk and combined Pharmaceutical Dosage Form. First method is...