DEVELOPMENT AND VALIDATION OF METHOD FOR THE DETERMINATION OF NILOTINIB BY RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
A RP-HPLC method in Isocratic mode was developed for the estimation of Nilotinib in bulk and pharmaceutical dosage forms. The method was employed on C-18 column using Water and Acetonitrile in the ratio 50:50 v/v as mobile phase at a flow rate of 1mL/min.The UV detection wavelength selected was 254nm.The retention time for Nilotinib was found to be 3.874 min.The linearity for the method was observed in a concentration range of 5-250μg/mL with the correlation coefficient of 0.999.The developed method was validated as per ICH guidelines. The method was found to be simple, accurate and precise. The method has been applied for the determination of Nilotinib in pharmaceutical dosage forms.
Authors and Affiliations
Harika Myneni , G. S. Kumar
Keywords
Related Articles
- EP ID EP161460
- DOI -
- Views 109
- Downloads 0
A COMPARATIVE STUDY OF ANTI OXIDANT PROPERTIES IN COMMON INDIAN SPICES
The present study reports the anti-oxidant potential of the methanolic extract of three spices Syzygium aromaticum, Elettaria cardamom, Piper nigrum. The total phenolic content was high 36.63 mg GAE/g in the Syzygium aro...
A BRIEF STUDY ON MARIGOLD (TAGETES SPECIES): A REVIEW
Tagetes species belonging to family Asteraceae, are most common in plant kingdom, which is used in different areas like cosmetic preparation, medicines as well as it is most widely used as ornamentals. It is found in dif...
PHARMACOGNOSTICAL STANDARDIZATION AND ANTIMICROBIAL ACTIVITY OF LEAVES OF SYZYGIUM CUMINI (LINN.) FROM VARIOUS REGION OF NORTH INDIA
Syzygium cumini is one of the widely used medicinal plants in the treatment of various diseases in particular diabetes. In present investigation, the pharmacognostic study of Syzygium cumini leaf is carried out from diff...
PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANALGESIC ACTIVITY OF WILLUGHBEIA EDULISROXB AVAILABLE IN BANGLADESH
Purpose: The present study was an attempt to investigate the phytochemical constituent and to explore the analgesic activity of n- butanol fraction of ethanol extract ofWillughbeia edulis(Family: Apocynaceae). Methods: T...
ROLE OF FISH OIL AGAINST CANCER
Cancer represents the largest cause of mortality in the world as the millions of humans and animals die every year. Chemotherapy being a major treatment modality used for the control of advanced stages of malignancies an...