PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANALGESIC ACTIVITY OF WILLUGHBEIA EDULISROXB AVAILABLE IN BANGLADESH
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 7
Abstract
Purpose: The present study was an attempt to investigate the phytochemical constituent and to explore the analgesic activity of n- butanol fraction of ethanol extract ofWillughbeia edulis(Family: Apocynaceae). Methods: The n- butanol fraction of ethanol extract of Willughbeia eduliswas investigated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. Result:In the hot plate method, the extract caused significant (p<0.001) inhibition of pain response (64.65% and 77.32% at the doses of 250 and 500 mg/kg body weight). It was found that the extract caused an inhibition of writhing response induced by acetic acid in a dose dependent manner. The extract of Willughbeia edulisand Diclofenac sodium produced a significant (P< 0.01) inhibition of the second phase response in the acetic acid pain model while the two doses of the extract showed an analgesic effect in the first phase.Conclusion: The result indicates significant analgesic activity of Willughbeia edulison animal models which are comparable with those of standard drugs.
Authors and Affiliations
Shariful Haque, Linda Sharmin, Biplab Das
Keywords
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- EP ID EP90099
- DOI 10.7897/2230-8407.06784
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