OPTIMIZING ORAL DRUG DELIVERY USING LIPID BASED FORMULATIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 7
Abstract
A great challenge facing the pharmaceutical scientists is transforming the new pharmacologically active lipophilic compounds that are poorly water soluble into orally administered medications with sufficient bioavailability. Lipid-based drug delivery systems has shown a great potential in the oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Oral lipid-based formulations comprises of a broad range of oils, surfactants, and co-solvents. This review provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives. The properties of the various lipid excipients are discussed and the criteria for selection of excipients for lipid-based formulations are identified. Finally the future prospects of this technique have been addressed to expand the utility of lipid based drug delivery systems.
Authors and Affiliations
Zara Sheikh, Nabila Morshed
Keywords
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- EP ID EP137087
- DOI 10.7897/2230-8407.0507105
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