DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF DEFERIPRONE
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2018, Vol 7, Issue 6
Abstract
Selective and precise RP-HPLC method was developed for estimation of Deferiprone in pure form. Acetonitrile: 0.1% formic acid (70: 30 v/v) was used as optimized mobile phase during the method development at 280 nm. Retention time of Deferiprone was 3.942 min. The developed method was validated according to ICH guidelines in the range of 10μg/mL to 60μg/mL.The linearity of Deferiprone shows a co-relation coefficient of 0.999. Precision was found to be 1.77 (%RSD). Percentage mean recovery of Deferiprone was found to be 100.34%. The developed method can be successfully employed for the quality control analysis of Deferiprone in its pure form.
Authors and Affiliations
Badithala Siva Sai Kiran, Raja Sundararajan
Keywords
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