DEVELOPMENT AND VALIDATION OF SIMPLE UV-SPECTROPHOTOMETRIC METHOD OF QUANTIZATION OF ONDANSETRON HYDROCHLORIDE IN SOLID DOSAGE FORMULATIONS USING HYDROTROPIC SOLUBILIZATION TECHNIQUE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2017, Vol 9, Issue 5
Abstract
Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs are methanol, ethanol, chloroform, benzene, toluene etc. The main drawbacks of organic solvents include high cost, toxicity, and pollution. Organic solvents have numerous adverse effects caused by single exposure like dermatitis, headache, drowsiness, nausea, eye irritation and long term exposure causes serious effects such as neurological disorder, chronic renal failure, and liver damage. They should be replaced by other ecofriendly alternative sources. The present study is an attempt to show that solid can also be used to act as solvent precluding the use of organic solvents. A simple, safe and sensitive method of spectrophotometric determination of Ondansetron hydrochloride obeyed beers law in the concentration range of 10-50µg/ml at 310 nm. The results of analyses have been validated statistically for linearity, accuracy, precision, LOD and LOQ. The results of validation parameters also indicated that proposed method was found to be accurate, precise, reproducible, sensitive, and suitable for routine quality control analysis for estimation of Ondansetron Hydrochloride in solid dosage formulation.
Authors and Affiliations
Sanjay Jain, R. K. Maheshwari, Rajesh Kumar Nema, Indrajeet Singhvi
Keywords
Related Articles
- EP ID EP618314
- DOI 10.25004/IJPSDR.2017.090509
- Views 110
- Downloads 0
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ELETRIPTAN FAST DISSOLVING ORAL FILMS
The present study aimed at preparing fast dissolving oral films of Eletriptan as a model drug which is used for the migraine treatment. Fast dissolving dosage forms have acquired great importance in pharmaceutical indust...
PHYTOCHEMICAL SCREENING AND APHRODISIAC ACTIVITY OF ASPARAGUS RACEMOSUS
The plant Asparagus racemosus is widely distributed in the Himalayan and sub-Himalayan regions of India. Based on preliminary reports, there is a lot of interest in using the roots of this plant for treating sexual disor...
EVALUATION OF ANTI-FERTILITY POTENTIAL OF AQUEOUS EXTRACT OF BOUGAINVILLEA SPECTABILIS LEAVES IN SWISS ALBINO MICE
Population explosion is a major problem it is raising tremendously; this may affect drastically the economic growth. Sofamily planning has been promoted through several methods of contraception. A wide variety of synthet...
ISOLATION AND IDENTIFICATION OF STEROID AND FLAVONOID GLYCOSIDES FROM THE FLOWERS OF ALLIUM GRAMINEUM
The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranoside and isorhamnetin 3,7-di-O-β-glucopyranoside from the flowers of Allium gra...
IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS
Cancer is a serious health problem that recognized as a group of diseases involving uncontrolled cell growth. Majority of cancer chemotherapeutic agents have serious toxicity profile. Due to this use of these agents are...