Development and validation of spectrophotometeric method for simultaneous determination of simvastatin and ezetimibe in tablet formulations
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2010, Vol 23, Issue 4
Abstract
A versatile, accurate, precise and economic method for simultaneous determination of simvastatin and ezetimibe in fixed dose combination products was developed. The absorbance values at 236 nm and 234 nm of over line spectrum was used for the estimation of simvastatin and ezetimibe, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 4 – 16 μg /ml for simvastatin and 4-16 μg /ml for ezetimibe. The results of analyses have been validated statistically for linearity, accuracy and precision of the proposed method.
Authors and Affiliations
S Balaji, A Sunitha
Keywords
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