Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Olmesartan Medoxomil and Metoprolol Succinate in Bulk and Dosage Form
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 12
Abstract
Two UV Spectrophotometric methods have been developed for the simultaneous estimation of Olmesartan medoxomil and Metoprolol succinate in tablet dosage form using 0.1 N NaOH. First UV spectrophotometric method is simultaneous equation method at 248 nm and 274 nm. Second UV spectrophotometric method is area under curve method; area under curve in the range of 246-250 nm (for Olmesartan medoxomil) and 272-276 nm (for Metoprolol succinate) were selected for analysis. In both methods, linearity was found to be in the range of 1-12 µg/ml for Olmesartan medoxomil and 5-30 µg/ml for Metoprolol succinate. Proposed methods were found to be accurate, precise and reproducible and have been validated statistically.
Authors and Affiliations
Shailaja B. Jadhav*, Vaibhavi V. Kunjir, Swati K. Kupkar, Praveen D. Chaudhari.
Keywords
Related Articles
- EP ID EP86618
- DOI -
- Views 133
- Downloads 0
Fabrication and antibacterial evaluation of Chitosan/Poly(vinyl Alcohol)/Methylcellulose ternary blend film
The present study explores the fabrication of chitosan/poly(vinyl alcohol)/methylcellulose films in view of their increasing applications as antimicrobial packaging, wound dressing and antibacterial materials. The antim...
Isolation and characterization of Lactic Acid Bacteria from shrimp biowaste (Peanus monodon)
The purpose of the present work was to characterize promising starter culture of Lactic acid bacteria isolated from naturally fermented shrimp biowaste at coastal dumping areas of Visakhapatnam, Andhrapradesh. Eighteen...
Pharmacognostic and Phytochemical Evaluation of Roots of Eclipta prostrata.
Herbs are staging a comeback and have stood the test of time for their safety, efficacy, cultural acceptability and fewer side effects. Eclipta prostrata Linn. [Asteraceae] popularly known as “Bhringaraj” is a herb with...
Biodegradation of anthracene and dibenzothiophene in model oil by the desulfurizing cells of Micrococcus halobius ED3
Micrococcus halobius ED3 was isolated from the soil in Dehradun, Uttarakhand, India and investigated for its potential to remove polyaromatic hydrocarbons (PAH) like anthracene and polyaromatic sulfur heterocycles (PASH...
A Bibliometric research on Medicinal and Aromatic Plants: A Core Journal Study.
The a im of the s tudy i s to eva lua t e ant i s e rotone rgi c a c t ivi ty of e thyl a c e t a t e ext r a c t of Abrus precatorius leaves on a frog fundus strip by using sumatriptan as a standa...